-
Article
Open AccessCeramide releases exosomes with a specific miRNA signature for cell differentiation
Exosomes are well established effectors of cell–cell communication. Their role on maturation of embryonic cells located in hippocampus, seat of memory, is unknown. Here we show that ceramide facilitates releas...
-
Article
Open AccessHuman breast milk as source of sphingolipids for newborns: comparison with infant formulas and commercial cow’s milk
In the past two decades, sphingolipids have become increasingly appreciated as bioactive molecules playing important roles in a wide array of pathophysiology mechanisms. Despite advances in the field, sphingol...
-
Article
Open AccessMeasurement of CSF core Alzheimer disease biomarkers for routine clinical diagnosis: do fresh vs frozen samples differ?
Cerebrospinal fluid (CSF) amyloid-beta (Aβ) 42/40 ratio, threonine-181-phosphorylated-tau (p-tau), and total-tau (t-tau) represent core biomarkers of Alzheimer disease (AD). The recent availability of automate...
-
Article
Open AccessAcid sphingomyelinase as target of Lycium Chinense: promising new action for cell health
Sphingomyelin plays very important roles in cell function under physiological and pathological conditions. Physical and chemical stimuli produce reactive oxygen species that stimulate acid sphingomyelinase to ...
-
Article
Open AccessWhy high cholesterol levels help hematological malignancies: role of nuclear lipid microdomains
Diet and obesity are recognized in the scientific literature as important risk factors for cancer development and progression. Hypercholesterolemia facilitates lymphoma lymphoblastic cell growth and in time tu...
