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Article
Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1
Biochemical crosstalk between two or more histone modifications is often observed in epigenetic enzyme regulation, but its functional significance in cells has been difficult to discern. Previous enzymatic stu...
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Article
Open AccessA text-mining based analysis of 100,000 tumours affecting dogs and cats in the United Kingdom
Cancer is a major reason for veterinary consultation, especially in companion animals. Cancer surveillance plays a key role in prevention but opportunities for such surveillance in companion animals are limite...
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Article
Open AccessSuper-enhancer-guided map** of regulatory networks controlling mouse trophoblast stem cells
Trophectoderm (TE) lineage development is pivotal for proper implantation, placentation, and healthy pregnancy. However, only a few TE-specific transcription factors (TFs) have been systematically characterize...
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Article
Author Correction: ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors
In the version of this Article originally published, Supplementary Fig. 6j showed incorrect values for the LS and AG4 glutathione samples, and Fig. 5c and Supplementary Fig. 6j did not include all n = 6 samples f...
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Article
Open AccessTumor penetrating peptides inhibiting MYC as a potent targeted therapeutic strategy for triple-negative breast cancers
Overexpression of MYC oncogene is highly prevalent in many malignancies such as aggressive triple-negative breast cancers (TNBCs) and it is associated with very poor outcome. Despite decades of research, attempts...
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Article
ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors
Induced pluripotent stem cells (iPSCs), which are used to produce transplantable tissues, may particularly benefit older patients, who are more likely to suffer from degenerative diseases. However, iPSCs gener...
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Article
Open AccessMulti-layered global gene regulation in mouse embryonic stem cells
Embryonic stem (ES) cells derived from the inner cell mass of develo** embryos have tremendous potential in regenerative medicine due to their unique properties: ES cells can be maintained for a prolonged ti...
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Article
Open AccessCpG island-mediated global gene regulatory modes in mouse embryonic stem cells
Both transcriptional and epigenetic regulations are fundamental for the control of eukaryotic gene expression. Here we perform a compendium analysis of >200 large sequencing data sets to elucidate the regulato...
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Article
Telomerase activity-independent function of TERT allows glioma cells to attain cancer stem cell characteristics by inducing EGFR expression
Telomerase reverse transcriptase (TERT), the catalytic subunit of the enzyme telomerase, is robustly expressed in cancer cells. TERT enables cells to avoid chromosome shortening during repeated replication by ...
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Article
Open AccessHuman telomerase catalytic subunit (hTERT) suppresses p53-mediated anti-apoptotic response via induction of basic fibroblast growth factor
Although human telomerase catalytic subunit (TERT) has several cellular functions including telomere homeostasis, genomic stability, cell proliferation, and tumorigenesis, the molecular mechanism underlying an...
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Article
In vitro myogenic and adipogenic differentiation model of genetically engineered bovine embryonic fibroblast cell lines
Our current understanding of muscle and adipose tissue development has been largely restricted to the study of murine myogenic and adipogenic cell lines, since attempts to establish these cell lines from other...
