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  1. Article

    Open Access

    Complete biosynthesis of QS-21 in engineered yeast

    QS-21 is a potent vaccine adjuvant and remains the only saponin-based adjuvant that has been clinically approved for use in humans1,2. However, owing to the complex structure of QS-21, its availability is limited...

    Yuzhong Liu, **xi Zhao, Fei Gan, **aoyue Chen, Kai Deng, Samantha A. Crowe… in Nature (2024)

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  2. Article

    Open Access

    Deciphering triterpenoid saponin biosynthesis by leveraging transcriptome response to methyl jasmonate elicitation in Saponaria vaccaria

    Methyl jasmonate (MeJA) is a known elicitor of plant specialized metabolism, including triterpenoid saponins. Saponaria vaccaria is an annual herb used in traditional Chinese medicine, containing large quantities...

    **aoyue Chen, Graham A. Hudson, Charlotte Mineo, Bashar Amer… in Nature Communications (2023)

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  3. No Access

    Article

    In vitro prototy** and rapid optimization of biosynthetic enzymes for cell design

    The design and optimization of biosynthetic pathways for industrially relevant, non-model organisms is challenging due to transformation idiosyncrasies, reduced numbers of validated genetic parts and a lack of...

    Ashty S. Karim, Quentin M. Dudley, Alex Juminaga, Yongbo Yuan… in Nature Chemical Biology (2020)