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Caloric Restriction and Biomarkers of Aging
Calorie restriction (CR) is characterized by a reduction in calorie intake without malnutrition. In the context of geroscience, CR is a promising nutritional strategy that targets the biology of aging and ther...
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Article
Total daily energy expenditure has declined over the past three decades due to declining basal expenditure, not reduced activity expenditure
Obesity is caused by a prolonged positive energy balance1,2. Whether reduced energy expenditure stemming from reduced activity levels contributes is debated3,4. Here we show that in both sexes, total energy expen...
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Article
Technical report: an online international weight control registry to inform precision approaches to healthy weight management
Personalizing approaches to prevention and treatment of obesity will be a crucial aspect of precision health initiatives. However, in considering individual susceptibility to obesity, much remains to be learne...
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Article
Open AccessTotal energy expenditure is repeatable in adults but not associated with short-term changes in body composition
Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is understudied. We examin...
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Article
Changes in body weight, adherence, and appetite during 2 years of calorie restriction: the CALERIE 2 randomized clinical trial
The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy Phase 2 (CALERIE) study showed that individuals who are nonobese were able to undergo significant calorie restriction (CR), yet th...
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Article
Noninvasive neuromodulation of the prefrontal cortex in young women with obesity: a randomized clinical trial
Obesity is associated with reduced neurocognitive performance. Individuals with obesity show decreased activation in the left dorsolateral prefrontal cortex (DLPFC), a key brain region relevant to the regulati...
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Open AccessAssociation of nutrition club membership with markers of health: a cross sectional study
Nutrition clubs (NC) operate in community settings and provide members with nutrition education and meal replacements for weight management. NC are owned and operated by distributors of Herbalife products. The...
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Effectiveness of Workplace Weight Management Interventions: a Systematic Review
A systematic review was conducted of randomized trials of workplace weight management interventions, including trials with dietary, physical activity, environmental, behavioral, and incentive-based components....
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Open AccessNew fat free mass - fat mass model for use in physiological energy balance equations
The Forbes equation relating fat-free mass (FFM) to fat mass (FM) has been used to predict longitudinal changes in FFM during weight change but has important limitations when paired with a one dimensional energy ...
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Article
Use of cereal fiber to facilitate adherence to a human caloric restriction program
Background and aims: Caloric restriction (CR) attenuates biological aging in animal models but there is little information on the feasibility and efficacy of CR regimens in humans. We examined th...