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Article
Open AccessEffect of carbamazepine and gabapentin on excitability in the trigeminal subnucleus caudalis of neonatal rats using a voltage-sensitive dye imaging technique
The antiepileptic drugs carbamazepine and gabapentin are effective in treating neuropathic pain and trigeminal neuralgia. In the present study, to analyze the effects of carbamazepine and gabapentin on neuron...
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Chapter and Conference Paper
Effect of JM-1232(-), a New Sedative on Central Respiratory Activity in Newborn Rats
JM-1232(-), a newly manufactured isoindole derivative, shows sedative effect at a lower concentration compared with propofol. In the present study, we analyzed the response of the central respiratory activity ...
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Chapter and Conference Paper
Laudanosine has No Effects on Respiratory Activity but Induces Non-Respiratory Excitement Activity in Isolated Brainstem-Spinal Cord Preparation of Neonatal Rats
Laudanosine, a degradation of neuomuscular blocking agent atracurium, crosses the blood-brain barrier and is indicted to trigger seizures at high concentration. In Xenopus Oocytes expressing nicotinic acetylcholi...
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Chapter
Chemosensitive Neuronal Network Organization in the Ventral Medulla Analyzed by Dynamic Voltage-Imaging
Central chemosensitivity is critically important to maintain homeostasis. We have successfully applied a voltage-imaging technique to medullary slice and isolated brainstem-spinal cord preparations and analyze...
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Chapter
CO2-sensitivity of GABAergic Neurons in the Ventral Medullary Surface of GAD67-GFP Knock-in Neonatal Mice
We investigated the CO2 responsiveness of GABAergic neurons in the ventral medullary surface (VMS), a putative chemoreceptive area using a 67-kDa isoform of GABA-synthesizing enzyme (GAD67)-green fluorescence pro...
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Chapter and Conference Paper
The Cell-Vessel Architecture Model for the Central Respiratory Chemoreceptor
The group of Loeschcke established that the superficial ventrolateral medulla contains chemosensitive regions (see the reviews [1-3]). Later, the group of Nattie conducted experiments of acetazolamide microinj...
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Chapter and Conference Paper
Role of GABA in Central Respiratory Control Studied in Mice Lacking GABA-Synthesizing Enzyme 67-kDa Isoform of Glutamic Acid Decarboxylase
In in vivo adult mammals, the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) has been shown to play an essential role in the termination of the respiratory phase in the central respiratory rhythm gene...
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Chapter and Conference Paper
Mechanism of Propofol-Induced Central Respiratory Depression in Neonatal Rats
Propofol (2, 6-diisopropylphenol) is an intravenous anesthetic, which has been increasingly used for both the induction and maintenance of general anesthesia1, 2 as well as in critical care medicine.3 When propof...
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Chapter and Conference Paper
Functional Connection From the Surface Chemosensitive Region to the Respiratory Neuronal Network in the Rat Medulla
Although the ventral medullary surface (VMS) has previously been assumed to be the main site for central respiratory chemoreception in mammals, it has recently been argued that chemosensitive sites are widespr...
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Chapter
Respiratory Suppression Induced by Nicotine Withdrawal in the Neonatal Rat Brainstem
Maternal smoking is known to be one of the SIDS risk factors1. With maternal smoking, nicotine is transported through the placenta to a fetus, and nicotine concentration fluctuates in fetal blood2,3. Also smoking...
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Chapter
Optical Recording of The Neuronal Activity in The Brainstem-Spinal Cord
Recording of dynamic neuronal activities in the brainstem and spinal cord in the study of central respiratory control have been so far conducted mostly with conventional microelectrode techniques such as the w...
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Chapter
Respiratory Depression following Acute Hypoxia in Vagotomized and Carotid Sinus Nerve Denervated Cats
Hypoxic depression of respiration has been observed in carotid chemo-denervated animals1, 2, 3. Although there seems to be general agreement that this is a direct inhibitive effect of hypoxia on central neurones,...
