22 Result(s)
within
S. de Jong
Oncology
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Article
Open AccessCorrection: Glycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer
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Article
Open AccessGlycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer
Hypoxia-induced glycogen turnover is implicated in cancer proliferation and therapy resistance. Triple-negative breast cancers (TNBCs), characterized by a hypoxic tumor microenvironment, respond poorly to ther...
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Open AccessRobust metabolic transcriptional components in 34,494 patient-derived cancer-related samples and cell lines
Patient-derived bulk expression profiles of cancers can provide insight into the transcriptional changes that underlie reprogrammed metabolism in cancer. These profiles represent the average expression pattern...
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Open AccessNutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL
Tumour cell-selective activation of apoptosis by recombinant human TNF-related apoptosis-inducing ligand (rhTRAIL) is enhanced through co-activation of p53 by chemotherapeutic drugs. The novel anticancer agent...
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A bioinformatical and functional approach to identify novel strategies for chemoprevention of colorectal cancer
Comparing normal colorectal mucosa and adenomas focusing on deregulated pathways obtains insight into the biological processes of early colorectal carcinogenesis. Publicly available microarray expression data ...
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Open AccessDrug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis
Drug resistance is a major problem in ovarian cancer. Triggering apoptosis using death ligands such as tumour necrosis factor-related apoptosis inducing ligand (TRAIL) might overcome chemoresistance.
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Open AccessIdentification of genes and pathways associated with cytotoxic T lymphocyte infiltration of serous ovarian cancer
Tumour-infiltrating lymphocytes (TILs) are predictors of disease-specific survival (DSS) in ovarian cancer. It is largely unknown what factors contribute to lymphocyte recruitment. Our aim was to evaluate gene...
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Open AccessModest effect of p53, EGFR and HER-2/neu on prognosis in epithelial ovarian cancer: a meta-analysis
P53, EGFR and HER-2/neu are the most frequently studied molecular biological parameters in epithelial ovarian cancer, but their prognostic impact is still unequivocal. We performed a meta-analysis to more prec...
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Open AccessAbundant Fas expression by gastrointestinal stromal tumours may serve as a therapeutic target for MegaFasL
Although the tyrosine kinase inhibitor imatinib has been shown to be an active agent in patients with gastrointestinal stromal tumours (GIST), complete remissions are almost never seen and most patients finall...
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Open AccessThe ErbB signalling pathway: protein expression and prognostic value in epithelial ovarian cancer
Ovarian cancer is the most frequent cause of death from gynaecological cancer in the Western world. Current prognostic factors do not allow reliable prediction of response to chemotherapy and survival for indi...
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Open AccessIndomethacin induces apoptosis via a MRP1-dependent mechanism in doxorubicin-resistant small-cell lung cancer cells overexpressing MRP1
Small-cell lung cancers (SCLCs) initially respond to chemotherapy, but are often resistant at recurrence. The non-steroidal anti-inflammatory drug indomethacin is an inhibitor of multidrug resistance protein 1...
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Open AccessReply: The classification of p53 immunohistochemical staining results and patient outcome in ovarian cancer
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Open AccessFactors influencing p53 expression in ovarian cancer as a biomarker of clinical outcome in multicentre studies
The prognostic impact of p53 immunostaining in a large series of tumours from epithelial ovarian cancer patients in a two-centre study was analysed. The study population (n=476) comprised of a retrospective serie...
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Open AccessIndomethacin-induced activation of the death receptor-mediated apoptosis pathway circumvents acquired doxorubicin resistance in SCLC cells
Small-cell lung cancers (SCLCs) initially respond to chemotherapy but are often resistant at recurrence. A potentially new method to overcome resistance is to combine classical chemotherapeutic drugs with apop...
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Open AccessInduction of hyperammonia in irradiated hepatoma cells: a recapitulation and possible explanation of the phenomenon
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Open AccessDifferential modulation of the TRAIL receptors and the CD95 receptor in colon carcinoma cell lines
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and CD95 ligand (CD95L) are potent inducers of apoptosis in various tumour cell types. Death receptors DR4 and DR5 can induce and decoy receptor...
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Open AccessCytotoxicity of rhein, the active metabolite of sennoside laxatives, is reduced by multidrug resistance-associated protein 1
Anthranoid laxatives, belonging to the anthraquinones as do anthracyclines, possibly increase colorectal cancer risk. Anthracyclines interfere with topoisomerase II, intercalate DNA and are substrates for P-gl...
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Open AccessTelomere length in breast cancer patients before and after chemotherapy with or without stem cell transplantation
High-dose chemotherapy and peripheral blood stem cell transplantation (PBSCT) may accelerate telomere length loss in haematopoietic stem cells. As data including pre-and post-treatment samples are lacking, we ...
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Death Receptor Ligands, in Particular TRAIL, to Overcome Drug Resistance
The efficacy of chemotherapeutic drugs is hampered by the occurrence of intrinsic and acquired drug resistance. A variety of mechanisms cause drug-resistance. A final common factor, however, is the reduced cap...
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Open AccessDNA topoisomerase IIα and -β expression in human ovarian cancer
To study DNA topoisomerase IIα (Topo-IIα) and -β expression and regulation in human ovarian cancer, 15 ovarian tumour samples were investigated. To compare different levels of expression, the samples were scre...
