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Article
Open AccessDemonstration of nuclear gamma-ray polarimetry based on a multi-layer CdTe Compton camera
To detect and track structural changes in atomic nuclei, the systematic study of nuclear levels with firm spin-parity assignments is important. While linear polarization measurements have been applied to deter...
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Article
The Japan-Multimodal Intervention Trial for Prevention of Dementia (J-MINT): The Study Protocol for an 18-Month, Multicenter, Randomized, Controlled Trial
The Japan-multimodal intervention trial for prevention of dementia (J-MINT) is intended to verify the effectiveness of multi-domain interventions and to clarify the mechanism of cognitive improvement and deter...
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Article
X-ray Spectroscopy of Muonic Atoms Isolated in Vacuum with Transition Edge Sensors
High-resolution X-ray spectroscopy of the highly charged muonic atoms/ions isolated in vacuum is an ideal probe to explore quantum electrodynamics under extremely strong electric fields, which is one of the ma...
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Article
Zero-energy vortex bound state in the superconducting topological surface state of Fe(Se,Te)
Majorana quasiparticles in condensed matter are important for topological quantum computing1–3, but remain elusive. Vortex cores of topological superconductors may accommodate Majorana quasiparticles that appear ...
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Chapter and Conference Paper
Development of High-Efficiency Coal Gasification Technology
Coal gasification is a key technology for converting coal into substitute natural gas (SNG), the common feedstock for synthesis of chemicals and electricity generation. Now, the development of coal gasificatio...
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Article
Open AccessFOXA1 repression is associated with loss of BRCA1 and increased promoter methylation and chromatin silencing in breast cancer
FOXA1 expression correlates with the breast cancer luminal subtype and patient survival. RNA and protein analysis of a panel of breast cancer cell lines revealed that BRCA1 deficiency is associated with the do...
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Article
Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining
The E2 ubiquitin conjugating enzyme Ubc13 and the E3 ubiquitin ligases Rad18 and Rnf8 promote homologous recombination (HR)-mediated double-strand break (DSB) repair by enhancing polymerization of the Rad51 re...
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Article
Open AccessMicroRNA-574-3p, identified by microRNA library-based functional screening, modulates tamoxifen response in breast cancer
Most primary breast cancers express estrogen receptor α and can be treated via endocrine therapy using anti-estrogens such as tamoxifen; however, acquired endocrine resistance is a critical issue. To identify ...
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Chapter and Conference Paper
System Improvements for Exhaled Breath Measurement System
As many as 200 kinds of volatile organic compounds (VOCs) are included in human exhaled breath. Many papers using VOCs as a biomarker of respiratory diseases have been reported. However, it is very difficult t...
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Article
A novel therapeutic molecule against HTLV-1 infection targeting provirus
Human T-cell leukemia virus type 1 (HTLV-1), which causes adult T-cell leukemia (ATL) in humans, establishes a life-long latent infection. Current therapies are not very effective against HTLV-1-associated dis...
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Article
Development of a Digital Signal Processing System for the X-Ray Microcalorimeter Onboard ASTRO-H (II)
The Pulse Shape Processor is a digital signal processing electronics for the microcalorimeter instrument onboard ASTRO-H. Receiving digitized waveform (14 bit, 12.5 kHz sample) from 2×18 channels, two identica...
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Article
Antitumor efficacy of oncolytic herpes simplex virus adsorbed onto antigen-specific lymphocytes
Although several studies have reported that locally administering oncolytic viruses effectively targets malignancies, the efficacy of systemically administered oncolytic viruses is restricted. Recently, howeve...
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Article
Impact of novel oncolytic virus HF10 on cellular components of the tumor microenviroment in patients with recurrent breast cancer
Oncolytic viruses are a promising method of cancer therapy, even for advanced malignancies. HF10, a spontaneously mutated herpes simplex type 1, is a potent oncolytic agent. The interaction of oncolytic herpes...
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Article
Order to disorder optical phase transition in random photonic crystals
Transition process of optical modal properties induced by the introduction of randomness into random photonic crystals is investigated by a computational method. We analyze an impulse response of two-dimension...
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Article
Improvement of cardiac fibrosis in dystrophic mice by rAAV9-mediated microdystrophin transduction
Duchenne muscular dystrophy (DMD) is the most common form of the progressive muscular dystrophies characterized by defects of the dystrophin gene. Although primarily characterized by degeneration of the limb musc...
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Article
In/Si(111): Self-Assembled One and Two-Dimensional Electron Gases
We present angle-resolved photoemission measurements for ultrathin In films on Si(111). Depending on the coverage, this system self-organizes into a metallic monolayer with either 4×1 or v7×v3 symmetry relativ...
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Article
A phase I dose-escalation clinical trial of intraoperative direct intratumoral injection of HF10 oncolytic virus in non-resectable patients with advanced pancreatic cancer
In 2005, we initiated a clinical trial that examined the efficacy of the oncolytic virus HF10 to treat pancreatic cancer. Pancreatic cancer continues to have a high mortality rate, despite multimodal treatment...
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Article
Knockdown of Efp by DNA-modified small interfering RNA inhibits breast cancer cell proliferation and in vivo tumor growth
The estrogen-responsive gene Efp promotes the growth of breast cancer cells by stimulating the degradation of a negative cell-cycle regulator, 14-3-3σ, and is hence considered a suitable molecular target for b...
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Article
Tuneabilities of localized electromagnetic modes in random nanostructures for random lasing
The modal characteristics of localized electromagnetic waves inside random nanostructures are theoretically presented. It is crucial to know the tuneabilities of the localized modes systematically for demonstr...
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Article
DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2
Abnormal centrosome numbers arise in tumours and can cause multipolar mitoses and genome instability. Cdk2 controls normal centrosome duplication, but Chk1-dependent centrosome amplification also occurs after ...
