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Article
Restriction fragment length polymorphism (RFLP) of the human insulin receptor gene in Japanese: its possible usefulness as a genetic marker
Restriction fragment length polymorphism of the human insulin receptor gene was analyzed with a 4.2 Kb cDNA probe in Japanese normal subjects and Type 2 (nonsulin-dependent) diabetic patients. Restriction endo...
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Chapter
Therapeutic Approach for the Deteriorated Renal Function in IgA Nephropathy
Our experience concerning a prospective randomized trial of a cocktail scheme of prednisolone, cyclophophamide and warfarin or dipyridamole for deteriorated renal function in IgA nephropathy is reported.
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Article
Type 2 (non-insulin-dependent) diabetes mellitus associated with a mutation of the glucokinase gene in a Japanese family
Mutations were screened for in the glucokinase gene of 25 Japanese patients with Type 2 (non-insulin-dependent) diabetes mellitus. Each exon was scanned by electrophoresis of enzymatically amplified DNA segmen...
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Article
A case of anti-nuclear antibody negative systemic lupus erythematosus associated with penile ulcer
We report here an old male patient with anti-nuclear antibody (ANA) negative systemic lupus erythematosus (SLE) with active renal disease and penile ulcer. He revealed nephrotic syndrome, malar rash and oral u...
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Article
Synaptotagmin genes on mouse Chromosomes 1, 7, and 10 and human Chromosome 19
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Article
A case of sjögren's syndrome associated with sweet's syndrome
We report a case of Sjögren's syndrome whose clinical course had been indolent until the patient presented with Sweet's syndrome (acute febrile neutrophilic dermatosis). This patient showed renal failure and r...
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Article
Immuno-localization of sulphonylurea receptor 1 in rat pancreas
Aims/hypothesis. A sulphonylurea receptor, SUR1, and an inward rectifier potassium channel, Kir6.2, reconstitute the ATP-sensitive K+ channel that mediates glucose-induced insulin secretion in pa...
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Chapter
Structure and Function of ATP-Sensitive K+ Channels
ATP-sensitive K+channels(KATPchannels) were first described by NOMA (1983) in cardiac muscle using the patch clamp technique. KATP channels are characterized by channel inhibition with an increase in intracellula...
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Article
S20G mutation of the amylin gene is associated with Type II diabetes in Japanese
Aims/hypothesis. Amylin is a unique constituent peptide of the amyloid deposits found in pancreatic islets in many patients with Type II (non-insulin-dependent) diabetes mellitus. A previous stud...
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Article
Polymorphic variation in the CBLB gene in human type 1 diabetes
CBLB was evaluated as a candidate gene for type 1 diabetes (T1D) susceptibility based on its association with autoimmunity in animal models and its role in T-cell costimulatory signaling. Cblb is one of the two m...
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Article
KATP channels confer survival advantage in cocaine overdose
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Article
Niflumic acid-sensitive ion channels play an important role in the induction of glucose-stimulated insulin secretion by cyclic AMP in mice
We have previously reported that glucose-stimulated insulin secretion (GSIS) is induced by glucagon-like peptide-1 (GLP-1) in mice lacking ATP-sensitive K+ (KATP) channels (Kir6.2 ...
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Article
Open AccessMEK–ERK-dependent multiple caspase activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma cell death
Recently developed heavy ion irradiation therapy using a carbon beam (CB) against systemic malignancy has numerous advantages. However, the clinical results of CB therapy against glioblastoma still have room f...
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Article
Deficit combinato di GH, prolattina e TSH dell’adulto associato alla presenza di anticorpi anti-PIT-1
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Article
Hydrogen Gas Evolution From Water Dispersing Nanoparticles Irradiated With Gamma-Ray
Hydrogen gas evolution from water dispersing nanoparticles under60Co γ-ray irradiation was investigated under various conditions. Dispersion of TiO2, A12O3, ZnO, ZrO2 and CeO2 nanoparticles with average sizes of ...
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Article
Open AccessRole of major histocompatibility complex class II in the development of autoimmune type 1 diabetes and thyroiditis in rats
Although the MHC class II ‘u’ haplotype is strongly associated with type 1 diabetes (T1D) in rats, the role of MHC class II in the development of tissue-specific autoimmune diseases including T1D and autoimmun...
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Article
Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea
Clarification of the molecular mechanisms of insulin secretion is crucial for understanding the pathogenesis and pathophysiology of diabetes and for development of novel therapeutic strategies for the disease....
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Article
Obesity and muscle weakness as risk factors for mobility limitation in community-dwelling older Japanese women: A two-year follow-up investigation
To examine the combined association of obesity and low muscle strength with mobility limitation in older adults.
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Article
Association of dietary variety with body composition and physical function in community-dwelling elderly Japanese
To examine the associations of dietary variety with body composition and physical function in community-dwelling elderly Japanese
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Article
Dietary variety and decline in lean mass and physical performance in community-dwelling older Japanese: A 4-year follow-up study
To examine associations of dietary variety with changes in lean mass and physical performance during a 4-year period in an elderly Japanese population. Design: Four-year prospective study.
