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Article
Frailty Trajectories and Its Associated Factors in Japanese Older Adults
Associated factors for frailty development according to age group remain unclear.
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Article
Cross-Sectional and Longitudinal Associations of Creatinine-to-Cystatin C Ratio with Sarcopenia Parameters in Older Adults
Accumulating evidence from cross-sectional studies suggests that the serum creatinine-to-cystatin C ratio (CCR) may be a useful biomarker for sarcopenia. This study aimed to assess the cross-sectional and long...
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Article
Interaction of Eating Status and Dietary Variety on Incident Functional Disability among Older Japanese Adults
To examine whether eating status and dietary variety were associated with functional disability during a 5-year follow-up analysis of older adults living in a Japanese metropolitan area.
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Article
Difference between “Physical Fitness Age” Based on Physical Function and Chronological Age Is Associated with Obesity, Hyperglycemia, Depressive Symptoms, and Low Serum Albumin
This study aimed to (1) develop the physical fitness age, which is the biological age based on physical function, (2) evaluate the validity of the physical fitness age for the assessment of sarcopenia, and (3)...
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Article
Score-Based and Nutrient-Derived Dietary Patterns Are Associated with Depressive Symptoms in Community-Dwelling Older Japanese: A Cross-Sectional Study
This study evaluated associations of score-based and nutrient-derived dietary patterns with depressive symptoms in community-dwelling older Japanese.
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Article
Development of the Nutrition and Functionality Assessment (NFA) Among Older Adults in Japan
Develop and evaluate the feasibility and validity of the Nutrition and Functionality Assessment (NFA) which identifies “target” older adults who could benefit from a personalized program following evaluation o...
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Article
Open AccessEpac2a-null mice exhibit obesity-prone nature more susceptible to leptin resistance
The exchange protein directly activated by cAMP (Epac), which is primarily involved in cAMP signaling, has been known to be essential for controlling body energy metabolism. Epac has two isoforms: Epac1 and Ep...
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Article
Dietary variety and decline in lean mass and physical performance in community-dwelling older Japanese: A 4-year follow-up study
To examine associations of dietary variety with changes in lean mass and physical performance during a 4-year period in an elderly Japanese population. Design: Four-year prospective study.
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Article
Association of dietary variety with body composition and physical function in community-dwelling elderly Japanese
To examine the associations of dietary variety with body composition and physical function in community-dwelling elderly Japanese
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Article
Obesity and muscle weakness as risk factors for mobility limitation in community-dwelling older Japanese women: A two-year follow-up investigation
To examine the combined association of obesity and low muscle strength with mobility limitation in older adults.
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Article
Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea
Clarification of the molecular mechanisms of insulin secretion is crucial for understanding the pathogenesis and pathophysiology of diabetes and for development of novel therapeutic strategies for the disease....
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Article
Open AccessRole of major histocompatibility complex class II in the development of autoimmune type 1 diabetes and thyroiditis in rats
Although the MHC class II ‘u’ haplotype is strongly associated with type 1 diabetes (T1D) in rats, the role of MHC class II in the development of tissue-specific autoimmune diseases including T1D and autoimmun...
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Article
Hydrogen Gas Evolution From Water Dispersing Nanoparticles Irradiated With Gamma-Ray
Hydrogen gas evolution from water dispersing nanoparticles under60Co γ-ray irradiation was investigated under various conditions. Dispersion of TiO2, A12O3, ZnO, ZrO2 and CeO2 nanoparticles with average sizes of ...
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Article
Deficit combinato di GH, prolattina e TSH dell’adulto associato alla presenza di anticorpi anti-PIT-1
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Article
Open AccessMEK–ERK-dependent multiple caspase activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma cell death
Recently developed heavy ion irradiation therapy using a carbon beam (CB) against systemic malignancy has numerous advantages. However, the clinical results of CB therapy against glioblastoma still have room f...
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Article
Niflumic acid-sensitive ion channels play an important role in the induction of glucose-stimulated insulin secretion by cyclic AMP in mice
We have previously reported that glucose-stimulated insulin secretion (GSIS) is induced by glucagon-like peptide-1 (GLP-1) in mice lacking ATP-sensitive K+ (KATP) channels (Kir6.2 ...
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KATP channels confer survival advantage in cocaine overdose
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Article
Polymorphic variation in the CBLB gene in human type 1 diabetes
CBLB was evaluated as a candidate gene for type 1 diabetes (T1D) susceptibility based on its association with autoimmunity in animal models and its role in T-cell costimulatory signaling. Cblb is one of the two m...
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Article
S20G mutation of the amylin gene is associated with Type II diabetes in Japanese
Aims/hypothesis. Amylin is a unique constituent peptide of the amyloid deposits found in pancreatic islets in many patients with Type II (non-insulin-dependent) diabetes mellitus. A previous stud...
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Chapter
Structure and Function of ATP-Sensitive K+ Channels
ATP-sensitive K+channels(KATPchannels) were first described by NOMA (1983) in cardiac muscle using the patch clamp technique. KATP channels are characterized by channel inhibition with an increase in intracellula...
