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Chapter and Conference Paper
The Emphasis of Design Patterns in Expressing Expert Knowledge from a Technical Solution: A Framework for Continued Research
Digital engineering is a transformative strategy that leverages an integrated model-based approach to improve communication, decision making, design understanding, and acquisition efficiency of system developm...
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Reference Work Entry In depth
Transitioning from Observation to Patterns: A Real-World Example
The systems engineering community of practitioners, researchers, and educators are in the process of transitioning to model-based systems engineering within a broader context of digital engineering. Industry i...
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Article
Open AccessSample return of primitive matter from the outer Solar System
The last thirty years of cosmochemistry and planetary science have shown that one major Solar System reservoir is vastly undersampled in the available suite of extra-terrestrial materials, namely small bodies ...
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Living Reference Work Entry In depth
Transitioning from Observation to Patterns: A Real-World Example
The systems engineering community of practitioners, researchers, and educators are in the process of transitioning to model-based systems engineering within a broader context of digital engineering. Industry i...
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Article
Interphase fluorescence in situ hybridization in untreated AL amyloidosis has an independent prognostic impact by abnormality type and treatment category
The significance of interphase fluorescence in situ hybridization (iFISH) by regimen type was assessed in 692 immunoglobulin light-chain (AL) amyloidosis patients with iFISH at diagnosis. First-line treatment was...
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Chapter
Trapezius
A 45-year-old lady presents with burning pain over the trapezius and weakness of the shoulder girdle. She had a cervical lymph node biopsy 6 months ago, following which she had developed these symptoms. Examin...
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Article
Immunoparesis in newly diagnosed AL amyloidosis is a marker for response and survival
Immunoparesis is an adverse prognostic marker in plasma cell proliferative disorders. Its impact in AL amyloidosis has not been explored in depth. Newly diagnosed AL amyloidosis patients (n=998) were evaluated fo...
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Article
Open AccessErratum to: 36th International Symposium on Intensive Care and Emergency Medicine
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Article
Open Access36th International Symposium on Intensive Care and Emergency Medicine
P001 - Sepsis impairs the capillary response within hypoxic capillaries and decreases erythrocyte oxygen-dependent ATP efflux
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Article
Impact of cytogenetic classification on outcomes following early high-dose therapy in multiple myeloma
Early high-dose therapy (HDT), consisting of high-dose melphalan and autologous stem cell transplantation following doublet or triplet novel agent induction, is a preferred management strategy for transplant-e...
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Article
Open AccessAbnormal FISH in patients with immunoglobulin light chain amyloidosis is a risk factor for cardiac involvement and for death
Importance of interphase fluorescent in situ hybridization (FISH) with cytoplasmic staining of immunoglobulin FISH (cIg-FISH) on bone marrow is not well understood in light chain amyloidosis (AL). This is in cont...
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Article
Open AccessIdentification of novel modifiers of Aβ toxicity by transcriptomic analysis in the fruitfly
The strongest risk factor for develo** Alzheimer's Disease (AD) is age. Here, we study the relationship between ageing and AD using a systems biology approach that employs a Drosophila (fruitfly) model of AD in...
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Article
Long-term outcome with lenalidomide and dexamethasone therapy for newly diagnosed multiple myeloma
The combination of lenalidomide and dexamethasone (Len–Dex) is a commonly used initial therapy for newly diagnosed multiple myeloma (MM). Although the initial response rates and toxicity are well known, long-t...
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Article
Measles virus causes immunogenic cell death in human melanoma
Oncolytic viruses (OV) are promising treatments for cancer, with several currently undergoing testing in randomised clinical trials. Measles virus (MV) has not yet been tested in models of human melanoma. This...
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Article
Slip System Modification in NiAl
An effort to modify the slip vector in the B2 compound NiAl was undertaken to overcome the brittle failure associated with the <100> slip vector which typically operates in this compound. Alloying additions we...
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Chapter
Silver Markets and Business Customers: Opportunities for Industrial Markets?
Demographic change will pose distinct challenges for companies. The ratio of people over 65 years of age will rise in all triad countries. At the same time, the number of younger people, and thus recruits in a...
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Article
Open AccessAdipose atrophy in cancer cachexia: morphologic and molecular analysis of adipose tissue in tumour-bearing mice
Extensive loss of adipose tissue is a hallmark of cancer cachexia but the cellular and molecular basis remains unclear. This study has examined morphologic and molecular characteristics of white adipose tissue...
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Chapter and Conference Paper
Ultrasonic Characterization of Fatigue Cracks in Composite Materials
Microcracks occurring in composite structures due to combined fatigue and cryogenic loading can cause leakage and failure of the structure and can be difficult to detect in-service. In aerospace systems, these...
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Article
DNA Microarrays: Gene Expression Applications
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Article
Open AccessCancer gene therapy clinical trials: lessons for the future
