-
Article
Proteinase Resistance of Carnosine, Pyrrolylcarnosine and Salicylcarnosine
Objective: The resistance of carnosine, pyrrolylcarnosine (PC) and salicylcarnosine (SC) to the action of leucine aminopeptidase and carboxypeptidases B and Y was evaluated. Methods: Proteolysis of carnosine and ...
-
Article
Anti-Aggregation and Antioxidant Properties of a New Derivative of Acetylsalicylic Acid and Carnosine
The search for effective pharmaceutical agents which possess high antiaggregant and antioxidant activity, and simultaneously, lack negative side effects, is a highly relevant task for modern science. In this r...
-
Article
Comparison of Neurobehavioral Changes in Mice Treated with Mitochondrial Toxins—Rotenone and MPTP
In this study, the effects of chronic administration of low doses of the mitochondrial neurotoxins MPTP (4 mg/kg for 23 days) and rotenone (4 mg/kg for 7 days) in CD-1 mice were compared. A comparative assessm...
-
Article
Liposomal Drug with Carnosine and Lipoic Acid: Preparation, Antioxidant and Antiplatelet Properties
The conditions for producing phosphatidylcholine liposomes containing lipoic acid and carnosine together were determined. The obtained liposomes are 180–250-nm spherical particles with an efficiency of lipoic ...
-
Article
The Study of the Neuroprotective Effects of Carnosine in the Experimental Model of Focal Cerebral Ischemia/Reperfusion
Oxidative stress is one of the key factors responsible for brain tissue damage in ischemia; this points to the use of antioxidants under these conditions. One of the promising antioxidants for the therapy of i...
-
Article
Carnosine as an effective neuroprotector in brain pathology and potential neuromodulator in normal conditions
Carnosine (b-alanyl-l-histidine) is an endogenous dipeptide widely distributed in excitable tissues, such as muscle and neural tissues—though in minor concentrations in the latter. Multiple benefits have been att...
-
Article
Lipoylcarnosine: Synthesis, Study of Physico-Chemical and Antioxidant Properties, Biological Activity
Synthesis of lipoylcarnosine (LipС), a conjugated molecule based on two natural antioxidants, carnosine and α-lipoic acid, is described and its physico-chemical, antioxidant properties and biological activity ...
-
Article
Carnosine prevents the development of oxidative stress under the conditions of toxic action of cadmium
Protective effect of the natural dipeptide carnosine on the antioxidant system of rats under conditions of oxidative stress caused by chronic cadmium administration was investigated. Oxidative status of experi...
-
Article
The protective effect of (S)-trolox–carnosine on a human neuroblastoma SH-SY5Y cell culture under the impact of heavy metals
Evaluation of the dose-dependent effects of heavy metals on the viability of a human neuroblastoma SH-SY5Y cell culture showed that 50% cell death was observed in the presence of 5 × 10–4 М lead, 5 × 10–6 М cadmi...
-
Article
Carnosine (β-alanyl-L-histidine) increases the efficacy of learning under conditions of oxidative stress related to the development of conditioned response with negative reinforcement
Previously, using in vivo models hystidine containing dipeptide carnosine (β-alanyl-L-hystidine) was shown to inhibit the development of oxidative stress induced by such effects like hypoxia, ischemia and neur...
-
Article
The effect of the natural dipeptide carnosine on learning of rats under the conditions of negative reinforcement
-
Article
Effect of hypoxia on the state of tissues in samr1 and samp1 mice with various rates of aging
Senescence-accelerated SAMP1 mice were more sensitive to the negative effect of hypobaric hypoxia than SAMR1 mice (control). Low-temperature EPR spectroscopy showed that high sensitivity of SAMP1 mice is relat...
-
Article
Biological Activity of Novel Synthetic Derivatives of Carnosine
Two novel derivatives of carnosine—(S)-trolox-l-carnosine (STC) and (R)-trolox-l-carnosine (RTC) are characterized in terms of their antioxidant and membrane-stabilizing activities as well as their resistance to ...
-
Article
Application of multipotent mesenchymal stromal cells from human adipose tissue for compensation of neurological deficiency induced by 3-nitropropionic acid in rats
We evaluated possible therapeutic effect of multipotent mesenchymal stromal cells from human adipose tissue differentiated to neuronal phenotype with retinoic acid on Wistar rats subjected to toxic effect of 3...
-
Article
Biochemical and Physiological Evidence that Carnosine Is an Endogenous Neuroprotector Against Free Radicals
1. Carnosine, anserine, and homocarnosine are endogenous dipeptides concentrated in brain and muscle whose biological functions remain in doubt.
-
Chapter
Carnosine Protective Effect on Ischemic Brain in Vivo Study Using Proton Magnetic Resonance Spectroscopy
Carnosine (β-alanylhistidine) and related histidine-containing compounds (anserine, homocarnosine, homoanserine, N-acetylhistidine, N-acetylcarnosine, N-acetylhomocar-nosine, N-acetylserine) are involved in a ...
-
Article
Third symposium onAcetabularia
-
Article
Studies on the functions of the RNA polymerase components by means of mutations
It had been shown earlier, that RNA polymerase 13 S particles contain the large components with a molecular weight of about 3–105 and small subunits with a molecular weight of 4·104-1·105. These polymerase compon...
