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  1. Article

    Open Access

    Perspectives from Young South African and Zimbabwean Women on Attributes of Four (Placebo) Vaginal Microbicide Delivery Forms

    Incorporating end-user input into the design of new vaginal microbicides for women is key to optimizing their uptake, consistent use, and, ultimately, success in combatting the heterosexual HIV epidemic.

    R. Weinrib, E. N. Browne, M. K. Shapley-Quinn, A. van der Straten… in AIDS and Behavior (2020)

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  2. No Access

    Article

    The detection and clinical significance of peripheral regulatory CD4+CD25hiCD127low T cells in patients with non-small cell lung cancer

    In this study, we aimed to discuss the clinical significance of CD4+CD25hiCD127low regulatory T cells (Tregs) in the peripheral blood of patients with non-small cell lung cancer (NSCLC).

    J. Qiu, G. Che, F. Liu, X. Sha, S. Ju, H. Ma… in Clinical and Translational Oncology (2019)

  3. No Access

    Article

    Development of aluminosilicate glass fiber doped with high Pr3+ concentration for all-optical fiber isolator application

    A new SiO2–Al2O3–B2O3–Pr6O11 glass fiber with high Pr3+ concentration was developed by the melt quenching technique and the fiber drawing process for all-optical fiber isolator application. The thermal analysis w...

    K. Linganna, S. Ju, Y. Lee, W.-T. Han in Journal of Materials Science: Materials in… (2019)

  4. No Access

    Article

    Optical Absorption and EPR Studies on Gamma-Ray Irradiated RE3+-Doped Fluorophosphate Glasses

    We have studied the effect of γ-ray irradiation on optical absorption, emission and decay characteristics of RE3+ (RE = Sm, Eu and Dy)-doped fluorophosphate glasses. Electron paramagnetic resonance (EPR) study co...

    K. Linganna, S. Ju, Ch. Basavapoornima… in Journal of Inorganic and Organometallic Po… (2018)

  5. No Access

    Chapter

    Classification and Limits

    To keep our analysis reasonably brief, the present examination of the topic of headache classification in children and adolescents focuses only on the primary headache forms. Our main intention is to consider ...

    Umberto Balottin, S. Ju in Headache and Comorbidities in Childhood and Adolescence (2017)

  6. Article

    Open Access

    DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma

    Glaucoma is the leading cause of irreversible blindness and is characterized by slow and progressive degeneration of the optic nerve head axons and retinal ganglion cell (RGC), leading to loss of visual functi...

    K-Y Kim, G A Perkins, M S Shim, E Bushong, N Alcasid, S Ju… in Cell Death & Disease (2015)

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  7. No Access

    Article

    Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis

    Nonsense-mediated mRNA decay (NMD) is an RNA surveillance mechanism that requires upframeshift protein 1 (UPF1). This study demonstrates that human UPF1 exerts protective effects in a rat paralysis model based...

    K L Jackson, R D Dayton, E A Orchard, S Ju, D Ringe, G A Petsko, L E Maquat… in Gene Therapy (2015)

  8. No Access

    Article

    Orexin A-mediated stimulation of 3β-HSD expression and testosterone production through MAPK signaling pathways in primary rat Leydig cells

    Orexin A (ORA) regulates food intake, energy metabolism, gastrointestinal and reproductive functions.

    D. Zheng, Y. Zhao, Y. Shen, X. Chang, S. Ju… in Journal of Endocrinological Investigation (2014)

  9. No Access

    Article

    Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain

    Latrepirdine (Dimebon; dimebolin) is a neuroactive compound that was associated with enhanced cognition, neuroprotection and neurogenesis in laboratory animals, and has entered phase II clinical trials for bot...

    J W Steele, S Ju, M L Lachenmayer, J Liken, A Stock, S H Kim… in Molecular Psychiatry (2013)

  10. No Access

    Article

    Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model

    Latrepirdine (Dimebon) is a pro-neurogenic, antihistaminic compound that has yielded mixed results in clinical trials of mild to moderate Alzheimer's disease, with a dramatically positive outcome in a Russian ...

    J W Steele, M L Lachenmayer, S Ju, A Stock, J Liken, S H Kim… in Molecular Psychiatry (2013)

  11. Article

    Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery

    Autophagy is implicated in regulating cell death in activated T cells, but the underlying mechanism is unclear. Here, we show that inhibition of autophagy via Beclin 1 gene deletion in T cells leads to rampant...

    J R Kovacs, C Li, Q Yang, G Li, I G Garcia, S Ju… in Cell Death & Differentiation (2012)

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  12. No Access

    Article

    miR-155 promotes macroscopic tumor formation yet inhibits tumor dissemination from mammary fat pads to the lung by preventing EMT

    A micro-RNA, miR-155, is overexpressed in many types of cancer cells, including breast cancer, and its role(s) in tumor metastasis has been studied on a very limited basis. Tumor metastasis is a multi-step pro...

    X **ang, X Zhuang, S Ju, S Zhang, H Jiang, J Mu, L Zhang, D Miller, W Grizzle… in Oncogene (2011)

  13. No Access

    Article

    Identification of microRNA-target interaction in APRIL-knockdown colorectal cancer cells

    MicroRNAs (miRNAs) regulate mammalian gene expression by targeting mRNAs and have key roles in several cellular processes, including differentiation, development, apoptosis and cancer pathomechanisms. Our prev...

    F Wang, W Ding, J Wang, R **g, X Wang, H Cong, Y Wang, S Ju, H Wang in Cancer Gene Therapy (2011)

  14. No Access

    Article

    Epi-inositol regulates expression of the yeast INO1 gene encoding inositol-1-P synthase

    Myo-inositol exerts behavioral effects in animal models of psychiatric disorders and is effective in clinical trials in psychiatric patients. Interestingly, epi-inositol exerts behavioral effects similar to myo-i...

    A Shaldubina, S Ju, D L Vaden, D Ding, R H Belmaker, M L Greenberg in Molecular Psychiatry (2002)