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Article
Intestinal knockout of Nedd4 enhances growth of Apcmin tumors
Nedd4 (Nedd4-1) is an E3 ubiquitin ligase that belongs to the HECT family and comprises a C2-WW(n)-HECT domain architecture. Although it has been reported to regulate growth factor receptors and cellular signa...
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Open AccessAnalysis of the intra- and intertumoral heterogeneity of hypoxia in pancreatic cancer patients receiving the nitroimidazole tracer pimonidazole
Hypoxia is thought to be an adverse feature of pancreatic cancer, but direct measurement in patients is technically challenging. To address this, we characterised the intra/interpatient heterogeneity of hypoxi...
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Open AccessBRCA1 and BRCA2 mutations sensitize to chemotherapy in patient-derived pancreatic cancer xenografts
Germline mutations of the BRCA tumour suppressors have been associated with increased risk of pancreatic cancer. Clinical evidence suggests that these patients may be more sensitive to treatment with cisplatin...
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Article
A genome-wide association study of anorexia nervosa
Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded si...
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Article
Open AccessOverall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriers
The BRCA1/2 proteins are involved in regulation of cellular proliferation by DNA damage repair via homologous recombination. Therefore, BRCA1/2 mutation carriers with pancreatic cancer may have distinct biologic ...
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Article
Open AccessCharacterisation of Familial Colorectal Cancer Type X, Lynch syndrome, and non-familial colorectal cancer
Familial Colorectal Cancer Type X (FCCTX) is defined as individuals with colorectal cancer (CRC) who families meet Amsterdam Criteria-1 (AC1), but whose tumours are DNA-mismatch-repair-proficient, unlike Lynch...
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Article
Chemotherapy of MMR-deficient colorectal cancer
Colorectal cancer (CRC) continues to rank as the third most common cancer in Western society and the second leading cause of cancer death in North America. There are at least three distinct, and relatively dis...
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Article
Open AccessSubstantial unexplained variation in cancer risks for MLH1 and MSH2 mutation carriers
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Open AccessMetachronous colon cancer risk following surgery for first primary rectal cancer in Lynch syndrome
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Article
Type IV collagen-initiated signals provide survival and growth cues required for liver metastasis
The liver is a major site of metastasis for human malignancies, yet the factors that regulate tumor cell survival and growth in this organ remain elusive. Previously, we reported that M-27IGF−IR murine lung carci...
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Article
Open AccessPromoter methylation of Wnt5a is associated with microsatellite instability and BRAF V600E mutation in two large populations of colorectal cancer patients
In colorectal cancer (CRC), tumour microsatellite instability (MSI) status and CpG island methylator phenotype (CIMP) status are indicators of patient outcome, but the molecular events that give rise to these ...
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Article
Open AccessBody mass index in early adulthood and colorectal cancer risk for carriers and non-carriers of germline mutations in DNA mismatch repair genes
Carriers of germline mutations in DNA mismatch repair (MMR) genes have a high risk of colorectal cancer (CRC), but the modifiers of this risk are not well established. We estimated an association between body ...
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Article
Open AccessA large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants
Defective DNA repair has a causal role in hereditary colorectal cancer (CRC). Defects in the base excision repair gene MUTYH are responsible for MUTYH-associated polyposis and CRC predisposition as an autosomal r...
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Open AccessErratum: COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer
Correction to: British Journal of Cancer 102, 447–454. doi: 10.1038/sj.bjc.6605338 Upon online publication of the above article on 17 November last year (and now this issue), it was noted that two of the autho...
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Open AccessCOGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer
It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying th...
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Open AccessAssociation of apolipoprotein E polymorphisms and dietary factors in colorectal cancer
ApoE single nucleotide polymorphisms (SNPs) Cys112Arg (Epsilon-4), and Arg158Cys (Epsilon-2) have been implicated in cardiovascular and Alzheimer's disease, but their role in colorectal cancer (CRC) has not be...
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Article
Percutaneous Ethanol Injection of Unresectable Medium-to-Large-Sized Hepatomas Using a Multipronged Needle: Efficacy and Safety
Fine needles with an end hole or multiple side holes have traditionally been used for percutaneous ethanol injection (PEI) of hepatomas. This study retrospectively evaluates the safety and efficacy of PEI of u...
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Article
Very high incidence of familial colorectal cancer in Newfoundland: a comparison with Ontario and 13 other population-based studies
Newfoundland has the highest rate of colorectal cancer (CRC) of any Canadian province. In order to investigate the factors, especially genetic components, responsible for CRC we established the Newfoundland Co...
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Survival following repeat hepatectomy for metastatic colorectal cancer
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Predictive value of 3D computed tomography in assessing hepatic volumes prior to resection
