-
Article
Open AccessVEGF-ablation therapy reduces drug delivery and therapeutic response in ECM-dense tumors
The inadequate transport of drugs into the tumor tissue caused by its abnormal vasculature is a major obstacle to the treatment of cancer. Anti-vascular endothelial growth factor (anti-VEGF) drugs can cause ph...
-
Article
Evaluation of the Role of Ceacam1 in the Develo** Neonatal Brain and its Impact on Encephalopathy of Prematurity
Encephalopathy of prematurity subsumes the two main neuropathological disorders of preterm white matter injury and neuronal/axonal disease. Factors such as hypoxia-ischemia, drug exposure, hyperoxia and matern...
-
Article
Evaluation of trabecular bone healing by fractal analysis and digital subtraction radiography on digitized panoramic radiographs: a preliminary study
We have evaluated radiographic changes in mandibular bone texture before and after surgical therapies using fractal analysis and digital subtraction radiography (DSR).
-
Article
Mechanisms of tumour vascularisation
Tissue growth is highly dependent on the supply of oxygen and nutrients. This regulatory mechanism does not only apply to normal tissue but also to tumour tissue. In contrast to normal tissue, a tumour at the ...
-
Article
Neural driven angiogenesis by overexpression of nerve growth factor
Mechanisms regulating angiogenesis are crucial in adjusting tissue perfusion on metabolic demands. We demonstrate that overexpression of nerve growth factor (NGF) in brown adipose tissue (BAT) of NGF-transgeni...
-
Article
Vascular dysfunction as an additional pathomechanism in glutaric aciduria type I
Summary: The metabolic hallmark of glutaric aciduria type I (GA I) isthe deficiency of glutaryl-CoA dehydrogenase (GCDH) with subsequent accumulation of glutaric acid, 3-hydroxglutaric acid (3-OH-GA) and glutaco...
-
Chapter and Conference Paper
Einfluss des vaskulären Permeabilitätsfaktor VEGF auf die Tumorzelldissemination bei Patienten mit Ösophaguskarzinom
VEGF does not only induce neo-angiogenesis of malignant tumors but also increases vascular permeability and might facilitate tumor cell dissemination. The expression of VEGF, microvessel count and the incidenc...
-
Article
Endothelin and endothelin receptors A and B in the human testis
Human testicular capillaries interconnect Leydig cells and seminiferous tubules. Microcirculation and blood flow are therefore essential for the maintenance of spermatogenesis. The expression and the localisa...
-
Article
Expression of FLT4 and its ligand VEGF-C in acute myeloid leukemia
FLT4 represents a recently cloned member of class III receptor tyrosine kinases which include receptors for the angiogenic growth factor VEGF, namely FLT1 and KDR. The ligand of FLT4 has been identified as VEG...
-
Article
Angioarchitecture of the human spermatic cord
Human spermatic cords were investigated by means of cast preparations, light-microscopic examination and computer-aided 3-dimensional reconstructions from serial sections of paraffin-embedded material. After l...
-
Chapter
Sertoli Cell-Specific Gene Expression in Conditionally Immortalized Cell Lines
A set of conditionally immortalized Sertoli cell lines has recently been established in this laboratory from H-2K h -tsA58 transgenic mice (Walther et al., 1996)...
-
Chapter
Angioarchitecture of the Human Spermatic Cord
In the spermatic cord of all species investigated a tightly organized venous network around the testicular artery has been described, with certain species-specific differences (Hess et al., 1984; Noordhuizen-S...
-
Chapter
Endothelin-1 and Its Receptors in the Human Epididymis
Endothelin-1 (ET-1) is a potent vasoconstrictor localized for the first time in porcine aortic endothelial cells (Yanagisawa et al., 1988). Endothelin receptors can be classified as subtype A (ET-A) and subtyp...
-
Chapter
Functional Markers for Fetal and Postnatal Differentiation of Rat Leydig Cells
The aim of the present work was to establish morphological markers for the functional differentiation of Leydig cells in rat in order to study the origin, development and maturation of these cells. Two differe...
-
Chapter
Expression of VEGF and its Receptors and Capillary Density in Leydig Cell Tumors of the Human Testis
A close association can be observed between the Leydig cells and the capillaries of normal human testis (Ergün et al., 1996). A prerequisite for tumor growth is neoangiogenesis (Folkman, 1982). One of the angi...
-
Chapter
Morphological and Functional Aspects of the Human Spermatic Cord Veins
It is well known that varicocele of the testis may lead to a damage of testicular tissue and therefore is one etiologic factor for male infertility. Successful varicocele treatment may result in preserving or ...
-
Chapter
VEGF Modulates the Capillaries of the Human Epididymis
Vascular endothelial growth factor (VEGF), a high specific endothelial cell mitogen (Conn et al., 1990), stimulates angiogenesis and enhances endothelial permeability by fenestration of venular and capillary e...
-
Chapter
Microcirculation and the Vascular Control of the Testis
The arterial blood supply of the human testicular parenchyma within a testicular lobule demonstrates a segmental organization. In correlation to Leydig cells and seminiferous tubules within such a testicular t...
-
Article
Die vaskuläre Organisation des Plexus pampiniformis beim Mann und ihre Bedeutung bei der antegraden Sklerosierung der Varikozele testis
-
Article
Capillaries in the lamina propria of human seminiferous tubules are partly fenestrated
The three capillary parts of the microvasculature of the human testis, namely the arterial side inter-Leydig cell capillaries, the intramural capillaries, and the venous side inter-Leydig cell capillaries, wer...
