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Article
Open AccessExploiting docetaxel-induced tumor cell necrosis with tumor targeted delivery of IL-12
There is strong evidence that chemotherapy can induce tumor necrosis which can be exploited for the targeted delivery of immuno-oncology agents into the tumor microenvironment (TME). We hypothesized that docet...
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Article
Open AccessTargeting myeloid-derived suppressor cells in combination with primary mammary tumor resection reduces metastatic growth in the lungs
Solid tumors produce proteins that can induce the accumulation of bone marrow-derived cells in various tissues, and these cells can enhance metastatic tumor growth by several mechanisms. 4T1 murine mammary tum...
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Article
Open AccessBMS-754807 is cytotoxic to non-small cell lung cancer cells and enhances the effects of platinum chemotherapeutics in the human lung cancer cell line A549
Despite advances in targeted therapy for lung cancer, survival for patients remains poor and lung cancer remains the leading cause of cancer-related deaths worldwide. The type I insulin-like growth factor rece...
