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Article
Open AccessEnhancement of Bacillus thuringiensis toxicity by feeding Spodoptera littoralis larvae with bacteria expressing immune suppressive dsRNA
RNAi interference (RNAi) for insect pest control is often used to silence genes controlling vital functions, thus generating lethal phenotypes. Here, we propose a novel approach, based on the knockout of an im...
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Article
Open AccessESICM LIVES 2016: part one
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Article
Open AccessCerebral Autoregulation in Patients Treated With V-Vecmo For Severe Ards
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Chapter and Conference Paper
A 32 × 32-Channels Chip for X-Ray Pixel Detector Read-Out
In this paper we present a spectrometer realized by bump-bonding a 300-μm-pitch, 32 × 32-pixel silicon X-ray detector chip to a 0.35-μm CMOS, 3-cm2 read-out chip. The selftriggered, mixed analog-digital read-out ...
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Article
Hypericum perforatum L. extract does not inhibit 5-HT transporter in rat brain cortex
The hydroalcoholic extract of Hypericum perforatum L. is an effective antidepressant, although its mechanism of action is still unknown. It inhibits the synaptosomal uptake of serotonin (5-HT), dopamine and norad...
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Article
Effect ofd-fenfluramine on the indole contents of the rat brain after treatment with different inducers of cytochrome P450 isoenzymes
The effects of pretreatment with inducers of hepatic cytochrome P450 isoenzymes (phenobarbital, dexamethasone andβ-naphthoflavone) on the metabolism ofd-fenfluramine (d-F) and its acute and long-lasting indole-de...
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Article
Brain uptake and distribution of the potential memory enhancer CL 275,838 and its main metabolites in rats: relationship between brain concentrations and in vitro potencies on neurotransmitter mechanisms
The kinetics, brain uptake and distribution of CL 275,838, a potential memory enhancer, and its main metabolites (II and IV) were evaluated in rats after intraperitoneal doses of 5, 10 and 20 mg/kg. Brain maxi...
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Article
Solid-phase extraction of piribedil and its metabolites from plasma and urine without and after deconjugation, by high performance liquid chromatography
A new high performance liquid chromatographic procedure has been developed for the simultaneous quantification of piribedil (PD) and its three main basic metabolites in rat plasma and urine, without and after ...
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Article
Kinetics of piribedil and effects on dopamine metabolism: hepatic biotransformation is not a determinant of its dopaminergic action in rats
The importance of hepatic metabolism in relation to the central (dopaminergic) effects of piribedil (PD) is still not really known. Plasma and brain kinetics and the effects on striatal dopamine (DA) metabolis...
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Article
Single and multiple dose pharmacokinetics of etizolam in healthy subjects
The pharmacokinetics of etizolam, a new thienodiazepine derivative, has been examined after single and multiple (0.5 mg tablet) (0.5 mg b.d for 1 week) oral therapeutic doses in healthy volunteers. The single-...
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Article
Propranolol does not alter flutoprazepam kinetics and metabolism in the rat
The influence of propranolol on the disposition of flutoprazepam, a benzodiazepine derivative extensively biotransformed by hepatic microsomal oxidation, was evaluated in the rat Propranolol was infused subcut...
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Article
Influence of dose and route of administration on the kinetics of fluoxetine and its metabolite norfluoxetine in the rat
Fluoxetine (FL) is being used in neuropharmacology as a tool for studying various functional roles of serotoninergic neurons. Its kinetics was studied in rats, a species widely used in neurochemical studies, a...
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Chapter
Serotonin Transmission and Food Intake
Serotonin (5HT) injected into the rat paraventricular nucleus (PVN) of the hypothalamus reduces food intake and antagonizes the hyperphagia induced by noradrenaline administered in the same area (1). This effe...
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Article
Mode of action of tiaspirone on the central cholinergic system
Tiaspirone, a potential antipsychotic drug, reduced the acetylcholine content of rat hemispheric brain regions (striatum 35%, hippocampus 20%, cortex 32% with no effect on N. accumbens) at an oral dose of 40 m...
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Article
Kinetics and brain uptake of S 9795, a new xanthine derivate, in rats
The relationships between plasma and brain concentrations of S 9795 and its main metabolites after single intravenous doses of S 9795 were examined in rats by high-performance liquid chromatography with UV det...
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Chapter
Mechanism of action of anxiolytic drugs
Anxiolytic agents represent a class of compounds which in fact started with alcohol, barbiturates and meprobamate but was actually recognized when chlordiazepoxide, the prototype of the benzodiazepine (BDZ) fa...
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Article
Pharmacokinetics of fenfluramine and norfenfluramine in volunteers given d- and dl-fenfluramine for 15 days
The kinetics of accumulation and elimination of d- and l-fenfluramine (F) and norfenfluramine (NF) have been studied in 8 young healthy volunteers given daily doses of 60 mg of sugar-coated tablets of 20 mg dl...
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Chapter
Benzodiazepines
Drugs of the benzodiazepine class have been introduced in several areas of clinical practice over the past years (Zbinden and Randall 1967; Greenblatt and Shader 1974; Bellantuono et al. 1980). Among their variou...
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Article
Brain levels of tofizopam in the rat and relationship with benzodiazepine receptors
The effect of tofizopam on 3H-flunitrazepam binding was studied in rat hippocampus and cerebellum. Tofizopam (at a concentration of 10−7M) increased 3H-Flu binding through a 30% rise in the B max with no modifica...
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Article
Species differences in phenazeram kinetics and metabolism
The kinetic profiles of phenazepam and its hydroxylated derivative were compared in rat, dog, cat and man after administration of single oral doses of the parent compound. The absorption of phenazepam was reas...
