68 Result(s)

Article

The Royal College of Ophthalmologists guidelines on serum eye drops for the treatment of severe ocular surface disease: executive summary

S Rauz, S-Y Koay, B Foot, S B Kaye, F Figueiredo, M A Burdon, E Dancey… in Eye (2018)

Article

Phase I trial outcomes in older patients with advanced solid tumours

This study had two aims: (a) to test the hypothesis that advanced age is associated with lower levels of tolerability and clinical benefit to experimental Phase I trial agents; (b) to assess the validity of th...

K H Khan, T A Yap, A Ring, L R Molife, S Bodla, K Thomas… in British Journal of Cancer (2016)

Article

Complications of hyperglycaemia with PI3K–AKT–mTOR inhibitors in patients with advanced solid tumours on Phase I clinical trials

PI3K–AKT–mTOR inhibitors (PAMi) are promising anticancer treatments. Hyperglycaemia is a mechanism-based toxicity of these agents and is becoming increasingly important with their use in larger numbers of pati...

E Geuna, D Roda, S Rafii, B Jimenez, M Capelan, K Rihawi… in British Journal of Cancer (2015)

Article

The neutrophil–lymphocyte ratio and its utilisation for the management of cancer patients in early clinical trials

Inflammation is critical to the pathogenesis and progression of cancer, with a high neutrophil–lymphocyte ratio (NLR) associated with poor prognosis. The utility of studying NLR in early clinical trials is unk...

R Kumar, E Geuna, V Michalarea, M Guardascione, U Naumann… in British Journal of Cancer (2015)

Article

Objective evaluation of refractive data and astigmatism: quantification and analysis

The aim of this study was to present methods to improve the analysis of refractive data. A comparison of methods is used to analyse refractive powers using individual powers and aggregate data. Equations are a...

S B Kaye in Eye (2014)

Article

New perspectives on molecular targeted therapy in ovarian clear cell carcinoma

Ovarian clear cell carcinomas (OCCCs) account for about 5–13% of all epithelial ovarian carcinomas in Western populations. It is characterised by resistance to conventional platinum-based chemotherapy, and new...

D S P Tan, R E Miller, S B Kaye in British Journal of Cancer (2013)

Article

Association of creatine kinase and skin toxicity in phase I trials of anticancer agents

We investigated the association between skin rash and plasma creatine kinase (CK) levels in oncology phase I trials.

V Moreno Garcia, P Thavasu, M Blanco Codesido, L R Molife… in British Journal of Cancer (2012)

Article

Prediction of early death among patients enrolled in phase I trials: development and validation of a new model based on platelet count and albumin

Selecting patients with ‘sufficient life expectancy’ for Phase I oncology trials remains challenging. The Royal Marsden Hospital Score (RMS) previously identified high-risk patients as those with ⩾2 of the fol...

A Ploquin, D Olmos, D Lacombe, R A'Hern, A Duhamel, C Twelves… in British Journal of Cancer (2012)

Article

Functional imaging: what evidence is there for its utility in clinical trials of targeted therapies?

Key issues in early clinical trials of targeted agents include the determination of target inhibition, rational patient selection based on pre-treatment tumour characteristics, and assessment of tumour respons...

N Tunariu, S B Kaye, N M deSouza in British Journal of Cancer (2012)

Article

A retrospective analysis of clinical outcome of patients with chemo-refractory metastatic breast cancer treated in a single institution phase I unit

Novel approaches to treat chemo-refractory metastatic breast cancer (MBC) are currently under investigation. This retrospective series reviews the outcome of 70 MBC patients who have participated in 30 phase I...

A T Brunetto, D Sarker, D Papadatos-Pastos, R Fehrmann… in British Journal of Cancer (2010)

Article

The visual and refractive outcomes of combined and sequential penetrating keratoplasty, cataract extraction, and intraocular lens insertion

The aim of this study was to investigate the visual and refractive outcome of combined penetrating keratoplasty, cataract extraction, and intraocular lens insertion (triple procedure) compared with cataract su...

D Q Nguyen, L L Mumford, M N A Jones, W J Armitage, S D Cook, S B Kaye, D M Tole in Eye (2009)

Article

Reply: Clinical outcome and prognostic factors for patients treated within a phase I study: the Royal Marsden Hospital Experience

D Olmos, H-T Arkenau, J E Ang, J S de Bono, I Judson, S B Kaye in British Journal of Cancer (2008)

Article

Reply to Late spontaneous anterior dislocation of an intraocular lens (IOL) with the capsular bag

A Choudhary, S B Kaye in Eye (2006)

Article

Adjuvant bleomycin, vincristine and cisplatin (BOP) for high-risk stage I non-seminomatous germ cell tumours: a prospective trial (MRC TE17)

Adjuvant BEP (bleomycin, etoposide, cisplatin) is effective treatment for high-risk clinical stage I (HRCS1) non-seminomatous germ cell tumours (NSGCT), but the known toxicities of etoposide, and the expansion...

D P Dearnaley, S D Fossa, S B Kaye, M H Cullen, S J Harland… in British Journal of Cancer (2005)

Article

Late spontaneous anterior dislocation of an intraocular lens (IOL) with the capsular bag

A Choudhary, J Sahni, S B Kaye in Eye (2005)

Article

Bleomycin, vincristine, cisplatin/bleomycin, etoposide, cisplatin chemotherapy: an alternating, dose intense regimen producing promising results in untreated patients with intermediate or poor prognosis malignant germ-cell tumours

Patients with poor and intermediate prognosis metastatic germ-cell tumours (MGCTs) are at a significant risk of relapse after standard platinum-based chemotherapy. Novel treatment regimens are required to impr...

D A Anthoney, M J McKean, J T Roberts, A W Hutcheon, J Graham… in British Journal of Cancer (2004)

Article

Chemotherapy for ovarian cancer: yesterday, today and tomorrow

S B Kaye in British Journal of Cancer (2003)