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Article
Open AccessEGF-mediated inhibition of ubiquitin-specific peptidase 24 expression has a crucial role in tumorigenesis
In this study, several cancer-related proteins (Bax, p300, E2F4 and securin) have been proven to be substrates of ubiquitin-specific peptidase 24 (USP24), and relevance has been shown between USP24 and its sub...
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Article
Variants of ubiquitin-specific peptidase 24 play a crucial role in lung cancer malignancy
Ubiquitin is a critical modifier regulating the degradation and function of its target proteins during posttranslational modification. Here we found that ubiquitin-specific peptidase 24 (USP24) is highly expre...
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Article
Open AccessAnti-HMGB1 antibody reduces weight gain in mice fed a high-fat diet
Insulin resistance in obesity is believed to be propagated by adipose tissue and liver inflammation. HMGB1 is a multifunctional protein that is pro-inflammatory when released from cells. It has been previously...
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Article
New motion cueing algorithm for driving simulator based on variant harmonic wavelet
As one of key technologies in movement perception simulation, motion cueing algorithm (MCA) is usually used for exploiting driving simulator within limited workspace and bounded dynamic characteristics. Severa...
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Article
Multi-color flow cytometric immunophenoty** for detection of minimal residual disease in AML: past, present and future
Current chemotherapeutic regimens achieve CR in a large percentage of patients with AML. However, relapse after CR remains a significant problem. The presence of leukemic cells at levels too low to be detected...
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Article
Application of the International Prognostic Scoring System-Revised in therapy-related myelodysplastic syndromes and oligoblastic acute myeloid leukemia
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Article
Toll-like receptor alterations in myelodysplastic syndrome
Recent studies have implicated the innate immunity system in the pathogenesis of myelodysplastic syndromes (MDS). Toll-like receptor (TLR) genes encode key innate immunity signal initiators. We recently identifie...
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Article
Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells
Sp1 is important for the transcription of many genes. Our previous studies have shown that Sp1 is degraded in normal cell, but it is preserved in cancer cells during mitosis and exists a priori in the daughter ce...
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Article
Trisomy 11 in myelodysplastic syndromes defines a unique group of disease with aggressive clinicopathologic features
Trisomy 11 in myelodysplastic syndromes (MDS) is rare, with undefined clinical significance and is currently assigned to the International Prognostic Scoring System (IPSS) intermediate-risk group. Over a 15-ye...
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Article
Refractory anemia with ringed sideroblasts associated with marked thrombocytosis harbors JAK2 mutation and shows overlap** myeloproliferative and myelodysplastic features
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Article
Effect of workpiece interaction on circular saw cutting stability II: Experimental results