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  1. No Access

    Article

    A novel long non-coding RNA in the rheumatoid arthritis risk locus TRAF1-C5 influences C5 mRNA levels

    Long non-coding RNAs (lncRNAs) can regulate the transcript levels of genes in the same genomic region. These locally acting lncRNAs have been found deregulated in human disease and some have been shown to harb...

    T C Messemaker, M Frank-Bertoncelj, R B Marques, A Adriaans, A M Bakker… in Genes & Immunity (2016)

  2. No Access

    Article

    DNA methylation regulates the expression of CXCL12 in rheumatoid arthritis synovial fibroblasts

    In the search for specific genes regulated by DNA methylation in rheumatoid arthritis (RA), we investigated the expression of CXCL12 in synovial fibroblasts (SFs) and the methylation status of its promoter and...

    E Karouzakis, Y Rengel, A Jüngel, C Kolling, R E Gay, B A Michel… in Genes & Immunity (2011)

  3. No Access

    Article

    Regulated and constitutive expression of anti-inflammatory cytokines by nontransforming herpesvirus saimiri vectors

    Herpesviral saimiri-(HVS) mediated expression of bovine growth hormone was one of the first applications of an episomal viral vector for gene therapy. Meanwhile, the long-term persistence of HVS vectors has be...

    C Wieser, D Stumpf, C Grillhösl, D Lengenfelder, S Gay, B Fleckenstein… in Gene Therapy (2005)

  4. No Access

    Article

    Targeting cathepsin L (CL) by specific ribozymes decreases CL protein synthesis and cartilage destruction in rheumatoid arthritis

    The present study was undertaken to examine whether ribozymes cleaving specifically cathepsin L (CL) mRNA are able to decrease the synthesis of CL protease in rheumatoid arthritis synovial fibroblasts (RA-SF) ...

    J Schedel, C A Seemayer, T Pap, M Neidhart, S Kuchen, B A Michel, R E Gay… in Gene Therapy (2004)

  5. No Access

    Article

    Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3

    Matrix metalloproteinases (MMPs) are believed to be pivotal enzymes in the invasion of articular cartilage by synovial tissue in rheumatoid arthritis (RA). Here, we investigated the effects of gene transfer of...

    W H van der Laan, P H A Quax, C A Seemayer, L G M Huisman, E J Pieterman… in Gene Therapy (2003)

  6. No Access

    Article

    Inhibition of cartilage destruction by double gene transfer of IL-1Ra and IL-10 involves the activin pathway

    The objective of the study was to determine the effects and the molecular background of interleukin-1 receptor antagonist (IL-1Ra) and vIL-10 double gene transfer into human synovial fibroblasts from patients ...

    E Neumann, M Judex, F Kullmann, J Grifka, P D Robbins, T Pap, R E Gay… in Gene Therapy (2002)

  7. No Access

    Chapter

    Proteomics and Mass Spectrometry

    W. V. Bienvenut, M. Müller, P. M. Palagi… in Mass Spectrometry and Genomic Analysis (2001)

  8. No Access

    Article

    Immunohistological study on collagen in cartilage-bone metamorphosis and degenerative osteoarthrosis

    Unter Verwendung von spezifischen Antikörpern ist es möglich, mit Hilfe immunhistologischer Methoden die Verteilung der verschiedenen Kollagentypen und auch die Kollagensynthese einzelner Zellen zu verfolgen. ...

    S. Gay, P. K. Müller, C. Lemmen, K. Remberger, K. Matzen… in Klinische Wochenschrift (1976)

  9. No Access

    Article

    Characterization and distribution of collagen types in arterial heterografts originating from the calf carotis

    Die immunhistochemischen Ergebnisse zeigen in der Kollagentypenverteilung der Kalbscarotis den humanen arteriellen Gefäßen vergleichbare Befunde. Mechanisch präparierte, im dynamischen Verfahren mit Ficin beha...

    S. Gay, P. Walter, K. Kühn in Klinische Wochenschrift (1976)

  10. No Access

    Article

    Immunohistochemical evidence for the presence of collagen type III in human arterial walls, arterial thrombi, and in leukocytes, incubated with collagen in vitro

    Schnitte von arteriellen Gefäßwänden und von Thromben sowie Ausstriche von Leukocyten, die in vitro mit Kollagen Typ III inkubiert worden waren, wurden mit Hilfe der indirekten Immunfluorescenz auf die Verteil...

    S. Gay, L. Balleisen, K. Remberger, P. P. Fietzek… in Klinische Wochenschrift (1975)

  11. No Access

    Article

    Comparative investigation on the influence of human bovine collagen types I, II and III on the aggregation of human platelets

    Die Kollagentypen I, II and III von Mensch und Kalb weisen in löslicher und strukturierter Form deutliche Unterschiede in ihrer Wirkung auf die Aggregation menschlicher Thrombocyten auf.

    L. Balleisen, S. Gay, R. Marx, K. Kühn in Klinische Wochenschrift (1975)

  12. No Access

    Article

    Liver cirrhosis: Immunofluorescence and biochemical studies demonstrate two types of collagen

    Aus klein- und grobknotiger Lebercirrhose durch Pepsinbehandlung gelöstes Kollagen enthält zwei Kollagentypen (1,7 M und 2,5 M NaCl Präcipitat). Immunfluorescenzmikroskopisch konnte Kollagen Typ III, das dem 1...

    S. Gay, P. P. Fietzek, K. Remberger, M. Eder, K. Kühn in Klinische Wochenschrift (1975)