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Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations

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    Open Access

    Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions

    ZL006 and IC87201 have been presented as efficient inhibitors of the nNOS/PSD-95 protein-protein interaction and shown great promise in cellular experiments and animal models of ischemic stroke and pain. Here,...

    Anders Bach, Søren W. Pedersen, Liam A. Dorr, Gary Vallon… in Scientific Reports (2015)

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