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  1. Article

    Open Access

    Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions

    ZL006 and IC87201 have been presented as efficient inhibitors of the nNOS/PSD-95 protein-protein interaction and shown great promise in cellular experiments and animal models of ischemic stroke and pain. Here,...

    Anders Bach, Søren W. Pedersen, Liam A. Dorr, Gary Vallon… in Scientific Reports (2015)

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  2. No Access

    Article

    Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations

    PDZ domains are scaffolding modules in protein–protein interactions that mediate numerous physiological functions by interacting canonically with the C-terminus or non-canonically with an internal motif of pro...

    Søren W. Pedersen, Stine B. Pedersen, Louise Anker… in Nature Communications (2014)

  3. No Access

    Protocol

    Synthesis of Peptides Using Tert-Butyloxycarbonyl (Boc) as the α-Amino Protection Group

    The use of the tert-butyloxycarbonyl (Boc) as the Nα-amino protecting group in peptide synthesis can be advantageous in several cases, such as synthesis of hydrophobic peptides and peptides containing ester and t...

    Søren W. Pedersen, Christopher J. Armishaw… in Peptide Synthesis and Applications (2013)