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  1. Article

    Open Access

    Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation

    Chromodomain helicase DNA binding protein 4 (CHD4) is an ATPase subunit of the Nucleosome Remodelling and Deacetylation (NuRD) complex that regulates gene expression. CHD4 is essential for growth of multiple p...

    Sébastien Coassolo, Guillaume Davidson, Luc Negroni… in Nature Communications (2021)

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    Article

    Chromatin remodellers Brg1 and Bptf are required for normal gene expression and progression of oncogenic Braf-driven mouse melanoma

    Somatic oncogenic mutation of BRAF coupled with inactivation of PTEN constitute a frequent combination of genomic alterations driving the development of human melanoma. Mice genetically engineered to condition...

    Patrick Laurette, Sébastien Coassolo, Guillaume Davidson… in Cell Death & Differentiation (2020)