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  1. Article

    Open Access

    Effects of IL-6, JAK, TNF inhibitors, and CTLA4-Ig on knee symptoms in patients with rheumatoid arthritis

    This study aims to identify factors influencing the alleviation of knee joint symptoms in patients with rheumatoid arthritis treated with biologic or target synthetic disease-modifying antirheumatic drugs (b/t...

    Koichi Murata, Ryuji Uozumi, Takayuki Fujii, Akira Onishi in Scientific Reports (2024)

  2. Article

    Open Access

    Phase Ib/II study of nivolumab combined with palliative radiation therapy for bone metastasis in patients with HER2-negative metastatic breast cancer

    Radiation therapy (RT) can enhance the abscopal effect of immune checkpoint blockade. This phase I/II study investigated the efficacy and safety of nivolumab plus RT in HER2-negative metastatic breast cancer r...

    Masahiro Takada, Michio Yoshimura, Takeshi Kotake, Kosuke Kawaguchi in Scientific Reports (2022)

  3. Article

    Open Access

    Proton pump inhibitors affect capecitabine efficacy in patients with stage II–III colorectal cancer: a multicenter retrospective study

    The association between capecitabine efficacy and proton pump inhibitors (PPIs) is controversial. Here, we determined whether co-administration of PPIs affects the real-world effectiveness of capecitabine. Thi...

    Yoshiko Kitazume, Hitoshi Kawazoe, Ryuji Uozumi, Tomoe Yoshizawa in Scientific Reports (2022)

  4. Article

    Open Access

    Local application of Usag-1 siRNA can promote tooth regeneration in Runx2-deficient mice

    Runt-related transcription factor 2 (Runx2)-deficient mice can be used to model congenital tooth agenesis in humans. Conversely, uterine sensitization-associated gene-1 (Usag-1)-deficient mice exhibit supernumera...

    Sayaka Mishima, Katsu Takahashi, Honoka Kiso in Scientific Reports (2021)

  5. Article

    Open Access

    Olanzapine plus aprepitant, palonosetron, and dexamethasone for nausea and vomiting in patients with breast cancer receiving anthracycline: A retrospective study

    This study aimed to compare the antiemetic efficacy and safety of a four-drug combination with those of a standard three-drug combination in Japanese patients with breast cancer treated with anthracycline. We ...

    Hitoshi Kawazoe, Ryuji Uozumi, Akari Murakami, Michiko Yamashita in Scientific Reports (2018)