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Article
Analysis of risk factors for fatal renal complications after allogeneic hematopoietic cell transplantation
Various complications can influence hematopoietic cell transplantation (HCT) outcomes. Renal complications can occur during the early to late phases of HCT along with various factors. However, studies focusing...
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Article
Dexamethasone palmitate as an etoposide-free treatment for children with hemophagocytic lymphohistiocytosis after hematopoietic cell transplantation
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Article
Severe short-term adverse events in related bone marrow or peripheral blood stem cell donors
The incidence of severe adverse events (SAEs) and associated risk factors in hematopoietic cell transplantation donors needs to be clarified for related donors (relatives of the transplant recipient), whose cr...
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Article
A retrospective survey of patients who discontinued participation in the JPLSG HLH-2004 clinical trial
Although clinical trials have reported an improvement in the prognosis of hemophagocytic lymphohistiocytosis (HLH), current treatment outcomes are unsatisfactory, especially in severe cases. Most clinical tria...
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Chapter
Landscape for Regenerative Medicine Manufacturing in Japan
In Japan, 6 years have passed since two important regenerative medicine laws came into force in November 2014 — the Act on the Safety of Regenerative Medicine and the Pharmaceuticals, Medical Devices, and Othe...
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Article
Open AccessPredictive factors for the development of leukemia in patients with transient abnormal myelopoiesis and Down syndrome
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Article
Acquired dysfibrinogenemia: monoclonal λ-type IgA binding to fibrinogen caused lower functional plasma fibrinogen level and abnormal clot formation
We report a case of acquired dysfibrinogenemia with monoclonal gammopathy of undetermined significance presenting λ-type IgA M protein. The patient showed lower functional (0.4 g/dL) and normal immunological fibr...
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Article
Comparative analysis of graft-versus-host disease prophylaxis with tacrolimus in combination with methylprednisolone or methotrexate after umbilical cord blood transplantation
Post-transplant early immune disorders and engraftment failure/delay are major issues in unrelated umbilical cord blood transplantation (UCBT). We evaluated graft-versus-host disease (GVHD) prophylaxis approac...
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Article
Correction to: Factors predicting the recurrence of Epstein–Barr virus-associated hemophagocytic lymphohistiocytosis in children after treatment using the HLH-2004 protocol
The correct name of the first author should be ‘‘Ryu Yanagisawa’’, and not ‘‘Ryu Yanagaisawa’’ as given in the original publication of the article.
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Article
Outcomes in children with hemophagocytic lymphohistiocytosis treated using HLH-2004 protocol in Japan
Recent advances in intensive chemo- and immunotherapy have contributed to the outcome of hemophagocytic lymphohistiocytosis (HLH); however, the prognosis of HLH in children differs by HLH subtype. In Japan, se...
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Article
Neuroblastoma invading the kidney through the renal hilum
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Article
The role of evaluation in achieving the SDGs
This paper proposes a framework on Sustainable Development Goal (SDG) evaluation, arguing that attainment of the 17 goals and 169 related targets depends significantly on practice-based monitoring and evaluati...
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Article
Open AccessInterferon-α-inducible Dendritic Cells Matured with OK-432 Exhibit TRAIL and Fas Ligand Pathway-mediated Killer Activity
Active human dendritic cells (DCs), which efficiently induce immune responses through their functions as antigen-presenting cells, exhibit direct anti-tumour killing activity in response to some pathogens and ...
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Article
Intrathecal donor lymphocyte infusion for isolated leukemia relapse in the central nervous system following allogeneic stem cell transplantation: a case report and literature review
An 8-year-old boy with a bone marrow relapse of T cell acute lymphoblastic leukemia underwent stem-cell transplantation from a human leukocyte antigen (HLA)-haploidentical mother. Five months later, he relapse...
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Article
Open AccessReduced-toxicity myeloablative conditioning consisting of 8-Gy total body irradiation, cyclophosphamide and fludarabine for pediatric hematological malignancies
Conventional myeloablative conditioning (MAC) regimens often cause severe regimen-related toxicity (RRT). Furthermore, many patients suffer from poor quality of life in accordance with the increase in long-ter...
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Article
Risk factors for diabetes mellitus and impaired glucose tolerance following allogeneic hematopoietic stem cell transplantation in pediatric patients with hematological malignancies
Long-term surviving recipients of allogeneic hematopoietic stem cell transplantation (HSCT) often suffer from diabetes mellitus (DM). We sought to identify risk factors for the development of post-transplant ...
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Article
Association of IRF5 Polymorphisms with Susceptibility to Hemophagocytic Lymphohistiocytosis in Children
Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome and has a varied genetic background. The polymorphism of interferon regulatory factor 5 gene (IRF5) was reported to be associated with susc...
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Article
Successful Unrelated Cord Blood Transplantation Using a Reduced-Intensity Conditioning Regimen in a 6-Month-Old Infant with Congenital Neutropenia Complicated by Severe Pneumonia
Here we report the first successful unrelated cord blood transplantation (CBT) using reduced-intensity conditioning for the treatment of congenital neutropenia in a 6-month-old infant with complications of sev...
