14 Result(s)
within
Ruo**g Huang
Biomedicine
-
Article
Open AccessCord blood-derived biologics lead to robust axonal regeneration in benzalkonium chloride-injured mouse corneas by modulating the Il-17 pathway and neuropeptide Y
Umbilical cord blood-derived therapeutics, such as serum (UCS) and platelet-rich plasma (UCPRP), are popular treatment options in clinical trials and can potentially be utilized to address a clinically unmet n...
-
Article
Open AccessComprehensive analysis of the clinical and biological significances of cholesterol metabolism in lower-grade gliomas
As a component of membrane lipids and the precursor of oxysterols and steroid hormones, reprogrammed cholesterol metabolism contributes to the initiation and progression of multiple cancers. Thus, we aim to fu...
-
Article
Open AccessMolecular and clinical characterization of PTRF in glioma via 1,022 samples
Polymerase I and transcript release factor (PTRF) plays a role in the regulation of gene expression and the release of RNA transcripts during transcription, which have been associated with various human diseases....
-
Article
Open AccessMaternal Western diet mediates susceptibility of offspring to Crohn’s-like colitis by deoxycholate generation
The Western dietary pattern, characterized by high consumption of fats and sugars, has been strongly associated with an increased risk of develo** Crohn’s disease (CD). However, the potential impact of mater...
-
Article
Long non-coding RNA MSTRG.81401 short hairpin RNA relieves diabetic neuropathic pain and behaviors of depression by inhibiting P2X4 receptor expression in type 2 diabetic rats
Patients with diabetic neuropathic pain (DNP) experience immense physical and mental suffering, which is comorbid with other mental disorders, including major depressive disorder (MDD). P2X4 receptor, one of t...
-
Article
4-Phenylcoumarins from Mesua ferrea with selective CYP1B1 inhibitory activity
Three new 4-phenylcoumarins, mesuaferlinns A–C (1–3), together with ten other known 4-phenylcoumarins, 4–13, were isolated from the branches and leaves of Mesua ferrea Linn. (Clusiaceae). The structure of compoun...
-
Article
Abnormal functional connectivity of the salience network in insomnia
The salience network plays an important role in detecting stimuli related to behavior and integrating neural processes. The aim of this study was to investigate changes in functional connectivity of the salien...
-
Article
Open AccessDifferent next-generation sequencing pipelines based detection of tumor DNA in cerebrospinal fluid of lung adenocarcinoma cancer patients with leptomeningeal metastases
The nucleic acid mutation status in intracranial metastasis is markedly significant clinically. The goal of the current study was to explore whether the tumor-associated mutations can be detected by different ...
-
Article
Open AccessADAR3 expression is an independent prognostic factor in lower-grade diffuse gliomas and positively correlated with the editing level of GRIA2Q607R
RNA editing by adenosine deaminases acting on RNA (ADARs) converts adenosines to inosines (A-to-I) in RNA, that alters gene expression and generates protein diversity. Dysregulation of A-to-I editing has been ...
-
Article
Mesenchymal stromal cell-derived extracellular vesicles: regenerative and immunomodulatory effects and potential applications in sepsis
Mesenchymal stromal (stem) cells (MSCs) have multipotent differentiation capacity and exist in nearly all forms of post-natal organs and tissues. The immunosuppressive and anti-inflammatory properties of MSCs ...
-
Article
Open AccessExpression profile analysis of antisense long non-coding RNA identifies WDFY3-AS2 as a prognostic biomarker in diffuse glioma
Increasing evidence has shown that long non-coding RNAs (lncRNAs) are important prognostic biomarkers and epigenetic regulators with critical roles in cancer initiation and progression. However, the expression...
-
Article
Open AccessErratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain
-
Article
Open AccessNetwork-driven plasma proteomics expose molecular changes in the Alzheimer’s brain
Biological pathways that significantly contribute to sporadic Alzheimer’s disease are largely unknown and cannot be observed directly. Cognitive symptoms appear only decades after the molecular disease onset, ...
-
Article
Open AccessMicroRNAs define distinct human neuroblastoma cell phenotypes and regulate their differentiation and tumorigenicity
Neuroblastoma (NB) is the most common extracranial solid tumor in children. NB tumors and derived cell lines are phenotypically heterogeneous. Cell lines are classified by phenotype, each having distinct diffe...
