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Article
Open AccessProteomic characterization identifies clinically relevant subgroups of soft tissue sarcoma
Soft tissue sarcoma is a broad family of mesenchymal malignancies exhibiting remarkable histological diversity. We portray the proteomic landscape of 272 soft tissue sarcomas representing 12 major subtypes. Hi...
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Article
Effect of Low-Temperature Thermal Oxidation on the Capillary Performance of Sintered Copper Powder Wicks
In this study, a composite powder capillary wick is prepared, manufactured by sintering copper powder and surface treated by low-temperature thermal oxidation. It is used to improve the performance of the capi...
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Article
Open AccessCorrelation of preoperative CT imaging shift parameters of the lateral plateau with lateral meniscal injury in Schatzker IV-C tibial plateau fractures
Schatzker IV-C is a high-energy tibial plateau fracture often accompanied by lateral meniscus injuries. While imaging examinations are routine preoperative measurements, the correlation between CT imaging shif...
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Article
Bioinformatic Analysis of the Potential Common Pathogenic Mechanisms for Psoriasis and Metabolic Syndrome
The pathogeneses of psoriasis and metabolic syndrome are closely related; however, the underlying biological mechanisms are yet to be clarified. A psoriasis training set was downloaded from the Gene Expression...
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Article
Comprehensive analysis of arachidonic acid metabolism-related genes in diagnosis and synovial immune in osteoarthritis: based on bulk and single-cell RNA sequencing data
Osteoarthritis (OA) is one of degenerative-related arthritis, which can be aggravated by low-grade synovitis. It is known that arachidonic acid (AA) dysmetabolism brings OA synovitis. However, the impact of sy...
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Article
Impact of cyclic bending on coronary hemodynamics
It remains unknown that the degree of bias in computational fluid dynamics results without considering coronary cyclic bending. This study aims to investigate the influence of different rates of coronary cycli...
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Article
Machine learning-based screening for biomarkers of psoriasis and immune cell infiltration
Psoriasis is a chronic immune-mediated skin disease. However, the pathogenesis is not yet well established.
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Article
A fast adaptive algorithm for training deep neural networks
Among the adaptive algorithms, Adam is the most widely used algorithm, especially for training deep neural networks. However, recent studies have shown that it has a weak generalization ability, and even canno...
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Article
Open AccessCorrection: Management of granulomatous lobular mastitis: an international multidisciplinary consensus (2021 edition)
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Article
Open AccessPlasmodium infection suppresses colon cancer growth by inhibiting proliferation and promoting apoptosis associated with disrupting mitochondrial biogenesis and mitophagy in mice
Colon cancer is a common gastrointestinal tumor with a poor prognosis, and thus new therapeutic strategies are urgently needed. The antitumor effect of Plasmodium infection has been reported in some murine models...
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Article
Open AccessManagement of granulomatous lobular mastitis: an international multidisciplinary consensus (2021 edition)
Granulomatous lobular mastitis (GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care f...
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Perianal Vegetations in a 1-Year-Old Child
Condyloma Acuminatum (CA) is a kind of proliferative lesion caused by human papillomavirus infection. Most of the patients are young people aged 18–35 years old with sexual ability. The disease is mainly trans...
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Chapter
A Female in Middle Age with Red Nodule
Dental Sinus is a multidisciplinary disease involving both teeth and skin. The diagnosis is usually made after skin lesions found. According to different parts, it can be divided into submental fistula and max...
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Chapter
A Male Student with a Scalp Nodule
Clear cell hidradenoma is a tumor originated from sweat gland, also known as nodular hidradenoma, solid cystic hidradenoma or eccrine acrospiroma. Clear cell hidradenoma is more common in middle-aged women, es...
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Chapter
A Middle-Aged Man with Erythema and Nodules on His Face
Leprosy is a chronic and low infectious disease caused by Mycobacterium leprae. The main route of transmission is long-term close contact with leprosy patients or through respiratory tract. Most people who are...
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Article
Open AccessDiosmetin inhibits cell proliferation and promotes apoptosis through STAT3/c-Myc signaling pathway in human osteosarcoma cells
Diosmetin is a bioflavonoid compound naturally abundant in citrus fruits. It is found to perform a variety of activities, while its antitumor property in osteosarcoma, a malignant tumor with unmet clinical tre...
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Article
Impact of left atrial appendage location on risk of thrombus formation in patients with atrial fibrillation
Most strokes in patients with atrial fibrillation (AF) are thought to arise from thrombus formation in the left atrial appendage (LAA). Assessing the hemodynamics in LAA and left atrium (LA) may provide some i...
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Article
The STING phase-separator suppresses innate immune signalling
Biomolecular condensates (biocondensates) formed via liquid–liquid phase-separation of soluble proteins have been studied extensively. However, neither the phase-separation of endoplasmic reticulum (ER) transm...
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Article
Open AccessEGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma
Glioblastoma (GBM) is the most common type of adult malignant brain tumor, but its molecular mechanisms are not well understood. In addition, the knowledge of the disease-associated expression and function of ...
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Article
Open AccessEffect of Ki-67 Expression Levels and Histological Grade on Breast Cancer Early Relapse in Patients with Different Immunohistochemical-based Subtypes
This retrospective analysis evaluated the interaction between Ki-67 and histological grade and their prognostic role in different breast cancer subtypes. In total, 2,573 breast cancer patients underwent surger...
