Abstract
It remains unknown that the degree of bias in computational fluid dynamics results without considering coronary cyclic bending. This study aims to investigate the influence of different rates of coronary cyclic bending on coronary hemodynamics. To model coronary bending, a multi-ring-controlled fluid–structural interaction model was designed. A coronary artery was simulated with various cyclic bending rates (0.5, 0.75 and 1 s, corresponding to heart rates of 120, 80 and 60 bpm) and compared against a stable model. The simulated results show that the hemodynamic parameters of vortex Q-criterion, temporal wall shear stress (WSS), time-averaged WSS (TaWSS) and oscillatory shear index (OSI) were sensitive to the changes in cyclic rate. A higher heart rate resulted in higher magnitude and larger variance in the hemodynamic parameters. Whereas, the values and distributions of flow velocity and relative residence time (RRT) did not show significant differences between different bending periods. This study suggests that a stable coronary model is not sufficient to represent the hemodynamics in a bending coronary artery. Different heart rate conditions were found to have significant impact on the hemodynamic parameters. Thus, cyclic bending should be considered to mimic the realistic hemodynamics in future patient-specific coronary hemodynamics studies.
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Acknowledgments
Computational resources and services used in this work were provided by the HPC and Research Support Group, Queensland University of Technology (QUT), Brisbane, Australia. As the receiver of Roland Bishop Award, Dr. Jiaqiu Wang would like to thank the Bishop family for their generous support of Biomedical Engineering Research.
Funding
This work was partially supported by the National Natural Science Foundation of China (Grant Nos. 12172089, 11972118, 61821002), the Australian Research Council (ARC) (Grant Number DP200103492), the Medical Research Future Fund (2016165), and the Early Career Researcher Grant funded by Centre for Biomedical Technologies.
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J.W. designed the study, setup the computational work, processed data and wrote the manuscript. R.F. and H.W. prepared figures 2-8. Y.X. processed the statistics. J.M., H.A., J.C. and P.P. participated on designing the study plan. Z.F. optimized the simulation setup. O.R. provided clinical insight on the results discussion. Z.L. supervised the study. All authors reviewed the final manuscript.
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Wang, J., Fang, R., Wu, H. et al. Impact of cyclic bending on coronary hemodynamics. Biomech Model Mechanobiol 22, 729–738 (2023). https://doi.org/10.1007/s10237-022-01677-z
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DOI: https://doi.org/10.1007/s10237-022-01677-z