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Article
Open AccessSerum levels of lipoprotein-associated phospholipase A2 are associated with coronary atherosclerotic plaque progression in diabetic and non-diabetic patients
Lp-PLA2 is linked to cardiovascular diseases and poor outcomes, especially in diabetes, as it functions as a pro-inflammatory and oxidative mediator.
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Article
Open AccessDAE-CFR: detecting microRNA-disease associations using deep autoencoder and combined feature representation
MicroRNA (miRNA) has been shown to play a key role in the occurrence and progression of diseases, making uncovering miRNA-disease associations vital for disease prevention and therapy. However, traditional lab...
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Article
Open AccessEnhanced tyrosine sulfation is associated with chronic kidney disease-related atherosclerosis
Chronic kidney disease (CKD) accelerates atherosclerosis, but the mechanisms remain unclear. Tyrosine sulfation has been recognized as a key post-translational modification (PTM) in regulation of various cellu...
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Article
Open AccessDifferent associations of general and abdominal obesity with upper and lower extremity artery disease among a community population in China
The associations between obesity and abnormalities of upper and lower extremity arteries remain to be elucidated. This study is aimed to investigate whether general obesity and abdominal obesity are associated...
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Article
Open Access[68Ga]Ga-DOTA-FAPI-04 PET/MR in patients with acute myocardial infarction: potential role of predicting left ventricular remodeling
To assess predictive value of 68Ga-labeled fibroblast activation protein inhibitor-04 ([68Ga]Ga-DOTA-FAPI-04) PET/MR for late left ventricular (LV) remodeling in patients with ST-segment elevated myocardial infar...
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Article
Open AccessSerum MPO levels and activities are associated with angiographic coronary atherosclerotic plaque progression in type 2 diabetic patients
The uncontrolled production of MPO promotes inflammation, oxidative stress and atherosclerosis. Serum MPO levels are increased in patients with diabetes compared with patients without diabetes.
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Article
Open AccessBiosafety and efficacy evaluation of a biodegradable magnesium-based drug-eluting stent in porcine coronary artery
Although the drug-eluting stent (DES) has become the standard for percutaneous coronary intervention (PCI)-based revascularization, concerns remain regarding the use of DES, mainly due to its permanent rigid c...
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Article
Open AccessSerum sLYVE-1 is not associated with coronary disease but with renal dysfunction: a retrospective study
Recent evidence has indicated that the lymphatic vessel endothelial hyaluronan receptor (LYVE-1) is implicated in chronic inflammation and the lymphatic immune response. The soluble form of LYVE-1 (sLYVE-1) is...
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Article
Open AccessIL-34 is associated with the presence and severity of renal dysfunction and coronary artery disease in patients with heart failure
Pro-inflammatory mediators are identified in patients with heart failure (HF), some of which may be used as biomarkers with diagnostic or prognostic value. As an additional ligand of Colony Stimulating Factor-...
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Article
Open AccessLow serum calcium is associated with left ventricular systolic dysfunction in a Chinese population with coronary artery disease
Whether serum calcium is associated with heart systolic function in patients with established coronary artery disease (CAD) and acute myocardial infarction (AMI) remains to be elucidated. This study is aimed t...
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Article
Open AccessProkineticin-2 is associated with metabolic syndrome in a middle-aged and elderly Chinese population
Prokineticin-2 is confirmed to be involved in the inflammatory process. Inflammation plays an important role in the pathogenesis of metabolic syndrome (MS). However, whether prokineticin-2 is associated with M...
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Article
Open AccessTetranectin as a Potential Biomarker for Stable Coronary Artery Disease
This cross-sectional study tested the hypothesis that decreased serum levels of tetranectin (TN), a regulator of the fibrinolysis and proteolytic system, is associated with the presence and severity of CAD. We...
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Article
Open AccessThe effects of low-dose Nepsilon-(carboxymethyl)lysine (CML) and Nepsilon-(carboxyethyl)lysine (CEL), two main glycation free adducts considered as potential uremic toxins, on endothelial progenitor cell function
Patients with chronic kidney disease (CKD) are at high risk of cardiovascular disease (CVD). Endothelial progenitor cell (EPCs) dysfunction plays a key role in this pathogenesis. Uremic retention toxins have b...
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Article
Open AccessInsulin resistance predicts progression of de novo atherosclerotic plaques in patients with coronary heart disease: a one-year follow-up study
The aim of our study was to explore and evaluate the relationship between insulin resistance and progression of coronary atherosclerotic plaques. With the great burden coronary heart disease is imposing on ind...
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Article
Open AccessSimultaneous feature selection and classification via Minimax Probability Machine
This paper presents a novel method for simultaneous feature selection and classification by incorporating a robust L1-norm into the objective function of Minimax Probability Machine (MPM). A fractional programmin...
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Article
Open AccessPlasma concentrations of osteopontin, but not thrombin-cleaved osteopontin, are associated with the presence and severity of nephropathy and coronary artery disease in patients with type 2 diabetes mellitus
The aim of the present cross-sectional study was to assess possible associations between osteopontin (OPN), and thrombin-cleaved (N-half) OPN, and nephropathy and coronary artery disease (CAD) in patients with...
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Article
Open AccessChromosome 9p21.3 polymorphism in a Chinese Han population is associated with angiographic coronary plaque progression in non-diabetic but not in type 2 diabetic patients
We sought to explore the association of variant rs1333049 on chromosome 9p21.3 with coronary artery disease (CAD) and angiographic plaque progression in non-diabetic and type 2 diabetic patients.
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Article
Open AccessNeointimal hyperplasia persists at six months after sirolimus-eluting stent implantation in diabetic porcine
Observational clinical studies have shown that patients with diabetes have less favorable results after percutaneous coronary intervention compared with the non-diabetic counterparts, but its mechanism remains...
