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Article
A confidence ellipse analysis for stochastic dynamics model of Alzheimer's disease
The Alzheimer’s disease (AD) is a neurodegenerative disease, which is caused by the aggregation of beta-amyloid peptide ( \(A\beta\) ...
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Article
Open AccessSubcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory
Ryanodine receptor 2 (RyR2) is abundantly expressed in the heart and brain. Mutations in RyR2 are associated with both cardiac arrhythmias and intellectual disability. While the mechanisms of RyR2-linked arrhy...
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Article
The correlation analyses of bacterial community composition and spatial factors between freshwater and sediment in Poyang Lake wetland by using artificial neural network (ANN) modeling
As one of the most important components of the lake ecosystem, microorganisms from the freshwater and sediment play an important role in many ecological processes. However, the difference and correlation of ba...
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Article
Microbial community assembly and metabolic function during wheat straw decomposition under different nitrogen fertilization treatments
In-depth microbial community characterization, a community-level metabolic function analysis, and biogeochemical assessments of residues were performed to understand the principles governing microbial communit...
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Article
Modulation of cardiac ryanodine receptor 2 by calmodulin
The high-conductance intracellular calcium (Ca2+) channel RyR2 is essential for the coupling of excitation and contraction in cardiac muscle. Among various modulators, calmodulin (CaM) regulates RyR2 in a Ca2+-de...
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Article
Differential responses of litter decomposition to nutrient addition and soil water availability with long-term vegetation recovery
The litter decomposition, nutrient patterns, as well as nutrient release and soil nutrient contents were determined in response to nitrogen (N) and phosphorus (P) addition and drought treatments following long...
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Article
Open AccessSex Ratio Elasticity Influences the Selection of Sex Ratio Strategy
There are three sex ratio strategies (SRS) in nature—male-biased sex ratio, female-biased sex ratio and, equal sex ratio. It was R. A. Fisher who first explained why most species in nature display a sex ratio of ...
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Article
Open AccessSpatial heterogeneity and host repression in fig-fig wasp mutualism
It is generally believed that physical heterogeneity in common resource or evolutionary restraint can sufficiently prevent direct conflict between host and symbionts in mutualism systems. Our data on fig/fig w...
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Article
The optimal sex ratio in cooperatively breeding populations
In some cooperatively breeding species, elder siblings remain within their home ranges to assist their parents in raising their younger siblings by providing protection or food. Previous attempts to model the ...
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Article
Open AccessAsymmetric or diffusive co-evolution generates meta-populations in fig-fig wasp mutualisms
Co-evolutionary theory assumes co-adapted characteristics are a positive response to counter those of another species, whereby co-evolved species reach an evolutionarily stable interaction through bilateral ad...
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Article
The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias
In heart muscle cells, sarcoplasmic reticulum calcium overload leads to spontaneous calcium waves that can cause arrhythmias and sudden cardiac death. S.R. Wayne Chen and his colleagues now detail the molecula...
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Article
Open AccessSpatial games and the maintenance of cooperation in an asymmetric Hawk-Dove game
Classical theories explaining the evolution of cooperation often rely on the assumption that the involved players are symmetrically interacted. However, in reality almost all well-documented cooperation system...
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Article
Open AccessCooperation in an asymmetric volunteer’s dilemma game with relatedness
What motivates some members of a social group to voluntarily incur costs in order to provide for the common good? This question lies at the heart of theoretical and empirical studies of cooperative behavior. T...
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Article
Carvedilol and its new analogs suppress arrhythmogenic store overload–induced Ca2+ release
The widely prescribed beta blocker carvedilol has strong antiarrhythmic effects on the heart, but the underlying mechanisms have been unclear. Qiang Zhou et al. now show that carvedilol, unlike other beta blocker...
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Article
Open AccessVarying coefficient analysis for indeterminate species interactions with non-parametric estimation, exemplifying with a fig-fig wasp system
Research on species interactions has generally assumed that species have a fixed interaction and therefore linear or non-linear parametric regression models (e.g. exponential, logistic) have been widely used t...
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Article
Asymmetric interaction will facilitate the evolution of cooperation
Explaining the evolution of cooperation remains one of the greatest problems for both biology and social science. The classical theories of cooperation suggest that cooperation equilibrium or evolutionary stab...
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Article
The evolution of cooperation in asymmetric systems
Explaining “Tragedy of the Commons” of evolution of cooperation remains one of the greatest problems for both biology and social science. Asymmetrical interaction, which is one of the most important characteri...
