64 Result(s)

Article

Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases

Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether pyroptosis can be a death form of MC remains unknown. Proteasom...

Zhan-Li Chen, Chen **e, Wei Zeng, Rui-Qi Huang… in Signal Transduction and Targeted Therapy (2024)

Article

Applying LASSO logistic regression for the prediction of biliary complications after ex vivo liver resection and autotransplantation in patients with end-stage hepatic alveolar echinococcosis

The purpose of this study was to explore the relevant risk factors associated with biliary complications (BCs) in patients with end-stage hepatic alveolar echinococcosis (HAE) following ex vivo liver resection...

**n Lin, Ying-Mei Shao, Rui-Qing Zhang… in European Journal of Medical Research (2024)

Article

A new TROP2-targeting antibody-drug conjugate shows potent antitumor efficacy in breast and lung cancers

Trophoblast cell surface antigen 2 (Trop2) is considered to be an attractive therapeutic target in cancer treatments. We previously generated a new humanized anti-Trop2 antibody named hIMB1636, and designated ...

Dan-dan Zhou, **ao-tian Zhai, Lan-wen Zhang, Zi-hui **e… in npj Precision Oncology (2024)

Article

‘Skip’ osteoporosis vertebral compression fractures caused by electrical injury: a case report and review of the literature

Electrical injuries rarely result in fractures, such as long bone fractures and spinal fractures. A few articles have reported osteoporosis vertebral compression fractures (OVCFs) caused by electrical injuries...

Ruili Jia, Yanhao Sun, Chong Liu, Rui-chao Liu… in Journal of Medical Case Reports (2024)

Article

Bone health and body composition in transgender adults before gender-affirming hormonal therapy: data from the COMET study

Preliminary data suggested that bone mineral density (BMD) in transgender adults before initiating gender-affirming hormone therapy (GAHT) is lower when compared to cisgender controls. In this study, we analyz...

C. Ceolin, A. Scala, M. Dall’Agnol… in Journal of Endocrinological Investigation (2024)

Article

Associations of medicine use and ejection fraction with the coexistence of frailty and sarcopenia in a sample of heart failure outpatients: a cross-sectional study

Frailty and sarcopenia have been extensively studied in heart failure (HF) patients, but their coexistence is unknown. The aim of this work is to describe the coexistence of these conditions in a sample of HF ...

Rui Valdiviesso, Teresa F. Amaral, Emília Moreira… in BMC Cardiovascular Disorders (2023)

Article

Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients

The Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infected a substantial proportion of Chinese population, and understanding the factors underlying the severity of the dis...

Lin Wang, Jia-Bao Cao, Bin-Bin **a, Yue-Juan Li… in Signal Transduction and Targeted Therapy (2023)

Article

Dynamic single-cell map** unveils Epstein‒Barr virus-imprinted T-cell exhaustion and on-treatment response

Epstein‒Barr virus (EBV)-associated gastric cancer (GC) manifests an intriguing immunotherapy response. However, the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains undefined...

Miao-Zhen Qiu, Chaoye Wang, Zhiying Wu, Qi Zhao… in Signal Transduction and Targeted Therapy (2023)

Article

Metformin accelerates bone fracture healing by promoting type H vessel formation through inhibition of YAP1/TAZ expression

Due to increasing morbidity worldwide, fractures are becoming an emerging public health concern. This study aimed to investigate the effect of metformin on the healing of osteoporotic as well as normal fractur...

Zhe Ruan, Hao Yin, Teng-Fei Wan, Zhi-Rou Lin, Shu-Shan Zhao, Hai-Tao Long… in Bone Research (2023)

Article

Effects of mixed oil emulsion on short-term clinical outcomes in premature infants: A prospective, multicenter, randomized controlled trial

This study compared the clinical effects of two different lipid emulsions in premature infants with gestational age < 32 weeks (VPI) or birth weight < 1500 g (VLBWI) to provide an evidence-based medicine basis...

Qing Yang, Juan Kong, Rui-Miao Bai, Wen-Ting Yu… in European Journal of Clinical Nutrition (2023)

Article

E3 ligase MG53 suppresses tumor growth by degrading cyclin D1

Due to the essential role of cyclin D1 in regulating transition from G1 to S phase in cell cycle, aberrant cyclin D1 expression is a major oncogenic event in many types of cancers. In particular, the dysregula...

Meng Fang, Hong-Kun Wu, Yumeng Pei, Yan Zhang… in Signal Transduction and Targeted Therapy (2023)

Article

Publisher Correction: Latent class analysis-derived classification improves the cancer-specific death stratification of molecular subty** in colorectal cancer

Wen Zhou, Ming-Ming He, Feng Wang, Rui-Hua Xu, Fang Wang, Qi Zhao in npj Precision Oncology (2023)

Article

Latent class analysis-derived classification improves the cancer-specific death stratification of molecular subty** in colorectal cancer

The molecular subtypes of colorectal cancer (CRC) represent a comprehensive dissection of CRC heterogeneity. However, molecular feature-based classification systems have limitations in accurately prognosticati...

Wen Zhou, Ming-Ming He, Feng Wang, Rui-Hua Xu, Fang Wang, Qi Zhao in npj Precision Oncology (2023)

Article

Noninvasive assessment of myocardial work during left ventricular isovolumic relaxation in patients with diastolic dysfunction

This study aims to investigate the value of myocardial work (MW) parameters during the isovolumic relaxation (IVR) period in patients with left ventricular diastolic dysfunction (LVDD).

Ying Guo, **ang Wang, Chen-guang Yang, Xu-yang Meng, Yi Li… in BMC Cardiovascular Disorders (2023)

Article

M7G-related molecular subtypes can predict the prognosis and correlate with immunotherapy and chemotherapy responses in bladder cancer patients

N7-methylguanosine (m7G) is closely associated with tumor prognosis and immune response in many cancer types. The correlation between m7G and bladder cancer (BC) needs further study. We aimed to orchestrate mo...

Deng-xiong Li, De-chao Feng, **ao-ming Wang… in European Journal of Medical Research (2023)

Article

Fc effector of anti-Aβ antibody induces synapse loss and cognitive deficits in Alzheimer’s disease-like mouse model

Passive immunotherapy is one of the most promising interventions for Alzheimer’s disease (AD). However, almost all immune-modulating strategies fail in clinical trials with unclear causes although they attenua...

**ao-ying Sun, **ao-lin Yu, Jie Zhu… in Signal Transduction and Targeted Therapy (2023)

Article

Application of metabolomics in urolithiasis: the discovery and usage of succinate

Urinary stone is conceptualized as a chronic metabolic disorder punctuated by symptomatic stone events. It has been shown that the occurrence of calcium oxalate monohydrate (COM) during stone formation is regu...

**u-zhen Zhang, **ong-xin Lei, Yan-lin Jiang… in Signal Transduction and Targeted Therapy (2023)

Article

Nucleic acid drug vectors for diagnosis and treatment of brain diseases

Nucleic acid drugs have the advantages of rich target selection, simple in design, good and enduring effect. They have been demonstrated to have irreplaceable superiority in brain disease treatment, while vect...

Zhi-Guo Lu, Jie Shen, Jun Yang, **g-Wen Wang… in Signal Transduction and Targeted Therapy (2023)