23 Result(s)

Article

DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer

Radiotherapy is one of the most common countermeasures for treating a wide range of tumors. However, the radioresistance of cancer cells is still a major limitation for radiotherapy applications. Efforts are c...

Rui-Xue Huang, **-Kun Zhou in Signal Transduction and Targeted Therapy (2020)

Article

VDR–SOX2 signaling promotes colorectal cancer stemness and malignancy in an acidic microenvironment

The acidic tumor microenvironment provides an energy source driving malignant tumor progression. Adaptation of cells to an acidic environment leads to the emergence of cancer stem cells. The expression of the ...

Pei-Shan Hu, Ting Li, **-Fei Lin… in Signal Transduction and Targeted Therapy (2020)

Article

NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications

Nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron donor in all organisms, and provides the reducing power for anabolic reactions and redox balance. NADPH homeostasis is regulated by ...

Huai-Qiang Ju, **-Fei Lin, Tian Tian, Dan **e… in Signal Transduction and Targeted Therapy (2020)

Article

Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial

Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Blocking CD147 via anti-CD147 antibody could suppress the in vitro SAR...

Huijie Bian, Zhao-Hui Zheng, Ding Wei… in Signal Transduction and Targeted Therapy (2021)

Article

Application of four nutritional risk indexes in perioperative management for esophageal cancer patients

The Prognostic Nutritional Index (PNI), Nutritional Risk Index (NRI), Geriatric Nutritional Risk Index (GNRI), and Controlling Nutritional Status (CONUT) score were devised for quantifying nutritional risk. Th...

Pei-yu Wang, **an-kai Chen, Qi Liu, Lei Xu… in Journal of Cancer Research and Clinical On… (2021)

Article

Tamoxifen and clomiphene inhibit SARS-CoV-2 infection by suppressing viral entry

Shulong Zu, Dan Luo, Lili Li, Qing Ye… in Signal Transduction and Targeted Therapy (2021)

Article

Long-term stability and protection efficacy of the RBD-targeting COVID-19 mRNA vaccine in nonhuman primates

Messenger RNA (mRNA) vaccine technology has shown its power in preventing the ongoing COVID-19 pandemic. Two mRNA vaccines targeting the full-length S protein of SARS-CoV-2 have been authorized for emergency u...

Hui Zhao, Tie-Cheng Wang, **ao-Feng Li… in Signal Transduction and Targeted Therapy (2021)

Article

sRAGE alleviates SARS-CoV-2-induced pneumonia in hamster

**uqin Zhang, Dan Li, Rui Sun, **nli Hu… in Signal Transduction and Targeted Therapy (2022)

Article

Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis

Metabolic enzymes have an indispensable role in metabolic reprogramming, and their aberrant expression or activity has been associated with chemosensitivity. Hence, targeting metabolic enzymes remains an attra...

**-Fei Lin, Pei-Shan Hu, Yi-Yu Wang… in Signal Transduction and Targeted Therapy (2022)

Article

Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and nontraditional risk factors. Genome-wide association combined with clonal lineage tracing and clinical trials have demonstra...

Peng Kong, Zi-Yang Cui, **ao-Fu Huang… in Signal Transduction and Targeted Therapy (2022)

Article

Prognostic implications of PPL expression in ovarian cancer

Periplakin (PPL) is a main member in plakin family, which plays important role in cellular adhesion complexes supporting and cytoskeletal integrity supplying. PPL was reported to be a potential biomarker candi...

Tian Hua, Bei-bei Zhao, Shao-bei Fan, Cai-fen Zhao, Yun-hong Kong… in Discover Oncology (2022)

Article

Nucleic acid drug vectors for diagnosis and treatment of brain diseases

Nucleic acid drugs have the advantages of rich target selection, simple in design, good and enduring effect. They have been demonstrated to have irreplaceable superiority in brain disease treatment, while vect...

Zhi-Guo Lu, Jie Shen, Jun Yang, **g-Wen Wang… in Signal Transduction and Targeted Therapy (2023)

Article

Application of metabolomics in urolithiasis: the discovery and usage of succinate

Urinary stone is conceptualized as a chronic metabolic disorder punctuated by symptomatic stone events. It has been shown that the occurrence of calcium oxalate monohydrate (COM) during stone formation is regu...

**u-zhen Zhang, **ong-xin Lei, Yan-lin Jiang… in Signal Transduction and Targeted Therapy (2023)

Article

Fc effector of anti-Aβ antibody induces synapse loss and cognitive deficits in Alzheimer’s disease-like mouse model

Passive immunotherapy is one of the most promising interventions for Alzheimer’s disease (AD). However, almost all immune-modulating strategies fail in clinical trials with unclear causes although they attenua...

**ao-ying Sun, **ao-lin Yu, Jie Zhu… in Signal Transduction and Targeted Therapy (2023)

Article

Efficacy and safety of different PD-1 inhibitors in combination with lenvatinib in the treatment of unresectable primary liver cancer: a multicentre retrospective study

Immune checkpoint inhibitors (ICIs) are safe and efficacious treatments for advanced primary liver cancer (PLC). The efficacy of different ICIs in the treatment of liver cancer remains unclear. The purpose of ...

Qi-mei Li, Qing-can Sun, Yan Jian, **g-zhe He, Hong-bo Zhu… in Discover Oncology (2023)

Article

Latent class analysis-derived classification improves the cancer-specific death stratification of molecular subty** in colorectal cancer

The molecular subtypes of colorectal cancer (CRC) represent a comprehensive dissection of CRC heterogeneity. However, molecular feature-based classification systems have limitations in accurately prognosticati...

Wen Zhou, Ming-Ming He, Feng Wang, Rui-Hua Xu, Fang Wang, Qi Zhao in npj Precision Oncology (2023)

Article

Publisher Correction: Latent class analysis-derived classification improves the cancer-specific death stratification of molecular subty** in colorectal cancer

Wen Zhou, Ming-Ming He, Feng Wang, Rui-Hua Xu, Fang Wang, Qi Zhao in npj Precision Oncology (2023)

Article

E3 ligase MG53 suppresses tumor growth by degrading cyclin D1

Due to the essential role of cyclin D1 in regulating transition from G1 to S phase in cell cycle, aberrant cyclin D1 expression is a major oncogenic event in many types of cancers. In particular, the dysregula...

Meng Fang, Hong-Kun Wu, Yumeng Pei, Yan Zhang… in Signal Transduction and Targeted Therapy (2023)

Article

Dynamic single-cell map** unveils Epstein‒Barr virus-imprinted T-cell exhaustion and on-treatment response

Epstein‒Barr virus (EBV)-associated gastric cancer (GC) manifests an intriguing immunotherapy response. However, the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains undefined...

Miao-Zhen Qiu, Chaoye Wang, Zhiying Wu, Qi Zhao… in Signal Transduction and Targeted Therapy (2023)

Article

Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients

The Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infected a substantial proportion of Chinese population, and understanding the factors underlying the severity of the dis...

Lin Wang, Jia-Bao Cao, Bin-Bin **a, Yue-Juan Li… in Signal Transduction and Targeted Therapy (2023)