56 Result(s)
within
Life Sciences
Stem Cells
Rui-** **ao
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Article
Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor
Activation of the heregulin/HER2 pathway in oestrogen receptor (ER)-positive breast-cancer cells leads to suppression of oestrogen-receptor element (ERE)-driven transcription and disruption of oestradiol respo...
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Dysregulation of HSG triggers vascular proliferative disorders
Vascular proliferative disorders, such as atherosclerosis and restenosis, are the most common causes of severe cardiovascular diseases, but a common molecular mechanism remains elusive. Here, we identify and c...
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Protein science research in China
Proteins are major executors of life processes, carrying out essential and nonessential functions inside and outside of the cell, in species ranging from simple unicellular organisms to mammals. Thus, not surp...
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Cdk1-phosphorylated CUEDC2 promotes spindle checkpoint inactivation and chromosomal instability
Aneuploidy and chromosomal instability are major characteristics of human cancer. These abnormalities can result from defects in the spindle assembly checkpoint (SAC), which is a surveillance mechanism for acc...
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Cell type specificity of signaling: view from membrane receptors distribution and their downstream transduction networks
Studies on cell signaling pay more attention to spatial dynamics and how such diverse organization can relate to high order of cellular capabilities. To overview the specificity of cell signaling, we integrate...
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Open AccessDirect reprogramming of porcine fibroblasts to neural progenitor cells
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Open AccessMesenchymal stem cells-regulated Treg cells suppress colitis-associated colorectal cancer
Previous studies have produced controversial results regarding whether mesenchymal stem cells (MSCs) promote or inhibit tumor development. Given the dual role of MSCs in inflammation and cancer, in this study ...
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Retinoic acid promotes primary fetal alveolar epithelial type II cell proliferation and differentiation to alveolar epithelial type I cells
Retinoic acid (RA) plays an important role in lung development and maturation. Many stimuli can induce alveolar epithelial cell damage which will result in the injury of lung parenchyma. The aim of this study ...
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Open AccessStructure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2
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Open AccessMetabolic activation of mitochondria in glioma stem cells promotes cancer development through a reactive oxygen species-mediated mechanism
Cancer stem cells (CSCs) possess characteristics associated with normal stem cells, specifically the abilities to renew themselves and to give rise to all cell types (differentiation). It is assumed that induc...
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Open AccessTreatment of periodontal intrabony defects using autologous periodontal ligament stem cells: a randomized clinical trial
Periodontitis, which progressively destroys tooth-supporting structures, is one of the most widespread infectious diseases and the leading cause of tooth loss in adults. Evidence from preclinical trials and sm...
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Article
A new cell line derived from embryonic tissues of Holotrichia parallela (Coleoptera:Scarabaeidae)
Holotrichia parallela is an important agricultural underground insect pest and also an edible and medicinal insect. Establishing a new cell line of H. parallela will provide a rapid and c...
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Open AccessProf. Huan-Yong Chen: a leading botanist and taxonomist, one of the pioneers and founders of modern plant taxonomy in China
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MiR-28 inhibits cardiomyocyte survival through suppressing PDK1/Akt/mTOR signaling
MicroRNAs play critical roles in regulating cell survival under multiple pathological conditions of heart diseases. Oxidative stress-induced apoptosis contributes greatly to heart ischemia-reperfusion injury. ...
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Open AccessInfluences of age-related changes in mesenchymal stem cells on macrophages during in-vitro culture
Mesenchymal stem cells (MSCs) have been widely used in cytotherapy and tissue engineering due to their immunosuppressive ability and regenerative potential. Recently, the immunomodulatory influence of MSCs has...
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Inhibition of two gastric cancer cell lines induced by fucoxanthin involves downregulation of Mcl-1 and STAT3
Fucoxanthin is a natural carotenoid that had never been previously demonstrated to have anti-tumor effect on human gastric adenocarcinoma SGC-7901 or BGC-823 cells. Here it was found to inhibit proliferation a...
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Open Access2-aminopurine suppresses the TGF-β1-induced epithelial–mesenchymal transition and attenuates bleomycin-induced pulmonary fibrosis
The epithelial–mesenchymal transition (EMT) is a multifunctional cell process involved in the pathogenesis of numerous conditions, including fibrosis and cancer. Idiopathic pulmonary fibrosis (IPF) is a progre...
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Open AccessCRISPR-Cas12a-assisted nucleic acid detection
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Open AccessSimulating the ion permeation and ion selection for a eukaryotic voltage-gated sodium channel NaVPaS
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Open AccessPolycomb protein family member CBX7 regulates intrinsic axon growth and regeneration
Neurons in the central nervous system (CNS) lose their intrinsic ability and fail to regenerate, but the underlying mechanisms are largely unknown. Polycomb group (PcG) proteins, which include PRC1 and PRC2 co...
