56 Result(s)

Article

Endothelial progenitor cell-derived extracellular vesicles: the world of potential prospects for the treatment of cardiovascular diseases

Cardiovascular diseases (CVDs) have emerged as a predominant threat to human health, surpassing the incidence and mortality rates of neoplastic diseases. Extracellular vesicles (EVs) serve as vital mediators i...

De-**n Chen, Chuang-Hong Lu, Na Na, Rui-**ng Yin, Feng Huang in Cell & Bioscience (2024)

Article

Thrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson’s disease

The neurotoxic α-synuclein (α-syn) oligomers play an important role in the occurrence and development of Parkinson’s disease (PD), but the factors affecting α-syn generation and neurotoxicity remain unclear. W...

**ao-yun Niu, **-xiu **e, Hou-zhen Tuo, Cui-** Lv, Ya-ru Huang… in Cell Death Discovery (2024)

Article

Arnicolide D induces endoplasmic reticulum stress-mediated oncosis via ATF4 and CHOP in hepatocellular carcinoma cells

Endoplasmic reticulum (ER) stress can trigger various cell death mechanisms beyond apoptosis, providing promise in cancer treatment. Oncosis, characterized by cellular swelling and increased membrane permeabil...

Yu-Shan Lin, Zhiwei Sun, Li-Sha Shen, Rui-Hong Gong, Jia-Wen Chen… in Cell Death Discovery (2024)

Article

IL-8 activates fibroblasts to promote the invasion of HNSCC cells via STAT3-MMP1

Matrix metalloproteinase-1 (MMP1) has an aberrant expression relevant to various behaviors of cancers. As dominant components of the tumor stroma, fibroblasts constitute an important source of Matrix metallopr...

Yu Chen, Li Huang, Rui-Huan Gan, Shuo Yuan, Ting Lan, Dali Zheng… in Cell Death Discovery (2024)

Article

NMDARs activation regulates endothelial ferroptosis via the PP2A-AMPK-HMGB1 axis

N-methyl-D-aspartate receptors (NMDARs) are ligand-gated, voltage-dependent channels of the ionotropic glutamate receptor family. The present study explored whether NMDAR activation induced ferroptosis in vasc...

Wei-Min Han, Yi-**ang Hong, Guo-Sheng **ao, Rui-Ying Wang, Gang Li in Cell Death Discovery (2024)

Article

YAP nuclear translocation induced by HIF-1α prevents DNA damage under hypoxic conditions

Maladaptive repair of acute kidney injury (AKI) is associated with a high risk of develo** chronic kidney disease deemed irremediable even in present days. When AKI arises from ischemia-reperfusion injury, h...

Heng-Ai Chang, Rui-Zhi Ou Yang, **g-Ming Su, Thi My Hang Nguyen… in Cell Death Discovery (2023)

Article

Human osteoarthritic articular cartilage stem cells suppress osteoclasts and improve subchondral bone remodeling in experimental knee osteoarthritis partially by releasing TNFAIP3

Though articular cartilage stem cell (ACSC)-based therapies have been demonstrated to be a promising option in the treatment of diseased joints, the wide variety of cell isolation, the unknown therapeutic targ...

Zhi-Ling Li, **ao-Tong Li, Rui-Cong Hao, Fei-Yan Wang… in Stem Cell Research & Therapy (2023)

Article

Stem cell-derived intestinal organoids: a novel modality for IBD

The organoids represent one of the greatest revolutions in the biomedical field in the past decade. This three-dimensional (3D) micro-organ cultured in vitro has a structure highly similar to that of the tissu...

Cheng-mei Tian, Mei-feng Yang, Hao-ming Xu, Min-zheng Zhu… in Cell Death Discovery (2023)

Article

TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m⁷G methylation of ATF5 mRNA

The mitochondrial transmembrane (TMEM) protein family has several essential physiological functions. However, its roles in cardiomyocyte proliferation and cardiac regeneration remain unclear. Here, we detected...

**n-Zhe Chen, **n-Min Li, Shi-Jun Xu, Shen Hu, Tao Wang… in Cell Death & Differentiation (2023)

Article

Amelioration of olfactory dysfunction in a mouse model of Parkinson’s disease via enhancing GABAergic signaling

Olfactory dysfunction is among the earliest non-motor symptoms of Parkinson’s disease (PD). As the foremost pathological hallmark, α-synuclein initiates the pathology in the olfactory pathway at the early stag...

**ng-Yang Liu, Ke Wang, **an-Hua Deng, Yi-Hua Wei, Rui Guo… in Cell & Bioscience (2023)

Article

Macrophages mediate psoriasis via Mincle-dependent mechanism in mice

Psoriasis is currently considered to be an immune and inflammatory disease characterized by massive immune cells infiltration including macrophages. It has been reported that macrophage-inducible C-type lectin...

Rui-zhi Tan, **a Zhong, Rang-yue Han, Ke-huan **e, Jian Jia… in Cell Death Discovery (2023)

Article

Author Correction: A single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy

Li-Heng Che, **g-Wen Liu, Jian-** Huo, Rong Luo, Rui-Min Xu, Cai He… in Cell Discovery (2023)

Article

CD36⁺ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor

Hepatocellular carcinoma (HCC) is an immunotherapy-resistant malignancy characterized by high cellular heterogeneity. The diversity of cell types and the interplay between tumor and non-tumor cells remain to b...

Gui-Qi Zhu, Zheng Tang, Run Huang, Wei-Feng Qu, Yuan Fang, Rui Yang… in Cell Discovery (2023)

Article

The roles of long noncoding RNAs in the regulation of OCT4 expression

OCT4 is a major transcription factor that maintains the pluripotency of stem cells, including embryonic stem cells, induced pluripotent stem cells and cancer stem cells. An increasing number of long noncoding ...

Rui-Ting Zhou, Yi-Ran Ni, Fan-Jun Zeng in Stem Cell Research & Therapy (2022)

Article

Correction to: Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT mediated up-regulation of GSK-3β and NRF2

Bo-Feng Yin, Zhi-Ling Li, Zi-Qiao Yan, Zheng Guo… in Stem Cell Research & Therapy (2022)

Article

Metformin combats high glucose-induced damage to the osteogenic differentiation of human periodontal ligament stem cells via inhibition of the NPR3-mediated MAPK pathway

High glucose-induced damage to the osteogenic differentiation of human periodontal ligament stem cells (PDLSCs) has long been a challenge to periodontal regeneration for diabetic individuals. Metformin is an a...

Yi-Lin Zhang, Fen Liu, Zhi-Bang Li, **ao-Tao He, Xuan Li… in Stem Cell Research & Therapy (2022)

Article

Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2

Repairing radiation-induced bone injuries remains a significant challenge in the clinic, and few effective medicines are currently available. Psoralen is a principal bioactive component of Cullen corylifolium (L....

Bo-Feng Yin, Zhi-Ling Li, Zi-Qiao Yan, Zheng Guo… in Stem Cell Research & Therapy (2022)

Article

METTL3-mediated macrophage exosomal NEAT1 contributes to hepatic fibrosis progression through Sp1/TGF-β1/Smad signaling pathway

Hepatic fibrosis (HF) is caused by chronic hepatic injury and is characterized by hepatic stellate cells (HSCs) activation. Studies focusing on the function of exosomes derived from macrophages in HF progressi...

Bo Shu, Rui-Zhi Zhang, Ying-**a Zhou, Chao He, **n Yang in Cell Death Discovery (2022)