24 Result(s)

Article

Thrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson’s disease

The neurotoxic α-synuclein (α-syn) oligomers play an important role in the occurrence and development of Parkinson’s disease (PD), but the factors affecting α-syn generation and neurotoxicity remain unclear. W...

**ao-yun Niu, **-xiu **e, Hou-zhen Tuo, Cui-** Lv, Ya-ru Huang… in Cell Death Discovery (2024)

Article

Arnicolide D induces endoplasmic reticulum stress-mediated oncosis via ATF4 and CHOP in hepatocellular carcinoma cells

Endoplasmic reticulum (ER) stress can trigger various cell death mechanisms beyond apoptosis, providing promise in cancer treatment. Oncosis, characterized by cellular swelling and increased membrane permeabil...

Yu-Shan Lin, Zhiwei Sun, Li-Sha Shen, Rui-Hong Gong, Jia-Wen Chen… in Cell Death Discovery (2024)

Article

IL-8 activates fibroblasts to promote the invasion of HNSCC cells via STAT3-MMP1

Matrix metalloproteinase-1 (MMP1) has an aberrant expression relevant to various behaviors of cancers. As dominant components of the tumor stroma, fibroblasts constitute an important source of Matrix metallopr...

Yu Chen, Li Huang, Rui-Huan Gan, Shuo Yuan, Ting Lan, Dali Zheng… in Cell Death Discovery (2024)

Article

NMDARs activation regulates endothelial ferroptosis via the PP2A-AMPK-HMGB1 axis

N-methyl-D-aspartate receptors (NMDARs) are ligand-gated, voltage-dependent channels of the ionotropic glutamate receptor family. The present study explored whether NMDAR activation induced ferroptosis in vasc...

Wei-Min Han, Yi-**ang Hong, Guo-Sheng **ao, Rui-Ying Wang, Gang Li in Cell Death Discovery (2024)

Article

YAP nuclear translocation induced by HIF-1α prevents DNA damage under hypoxic conditions

Maladaptive repair of acute kidney injury (AKI) is associated with a high risk of develo** chronic kidney disease deemed irremediable even in present days. When AKI arises from ischemia-reperfusion injury, h...

Heng-Ai Chang, Rui-Zhi Ou Yang, **g-Ming Su, Thi My Hang Nguyen… in Cell Death Discovery (2023)

Article

Stem cell-derived intestinal organoids: a novel modality for IBD

The organoids represent one of the greatest revolutions in the biomedical field in the past decade. This three-dimensional (3D) micro-organ cultured in vitro has a structure highly similar to that of the tissu...

Cheng-mei Tian, Mei-feng Yang, Hao-ming Xu, Min-zheng Zhu… in Cell Death Discovery (2023)

Article

TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m⁷G methylation of ATF5 mRNA

The mitochondrial transmembrane (TMEM) protein family has several essential physiological functions. However, its roles in cardiomyocyte proliferation and cardiac regeneration remain unclear. Here, we detected...

**n-Zhe Chen, **n-Min Li, Shi-Jun Xu, Shen Hu, Tao Wang… in Cell Death & Differentiation (2023)

Article

Macrophages mediate psoriasis via Mincle-dependent mechanism in mice

Psoriasis is currently considered to be an immune and inflammatory disease characterized by massive immune cells infiltration including macrophages. It has been reported that macrophage-inducible C-type lectin...

Rui-zhi Tan, **a Zhong, Rang-yue Han, Ke-huan **e, Jian Jia… in Cell Death Discovery (2023)

Article

Author Correction: A single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy

Li-Heng Che, **g-Wen Liu, Jian-** Huo, Rong Luo, Rui-Min Xu, Cai He… in Cell Discovery (2023)

Article

CD36⁺ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor

Hepatocellular carcinoma (HCC) is an immunotherapy-resistant malignancy characterized by high cellular heterogeneity. The diversity of cell types and the interplay between tumor and non-tumor cells remain to b...

Gui-Qi Zhu, Zheng Tang, Run Huang, Wei-Feng Qu, Yuan Fang, Rui Yang… in Cell Discovery (2023)

Article

METTL3-mediated macrophage exosomal NEAT1 contributes to hepatic fibrosis progression through Sp1/TGF-β1/Smad signaling pathway

Hepatic fibrosis (HF) is caused by chronic hepatic injury and is characterized by hepatic stellate cells (HSCs) activation. Studies focusing on the function of exosomes derived from macrophages in HF progressi...

Bo Shu, Rui-Zhi Zhang, Ying-**a Zhou, Chao He, **n Yang in Cell Death Discovery (2022)

Article

Identification of oligosaccharyltransferase as a host target for inhibition of SARS-CoV-2 and its variants

Yi-Jiao Huang, Hui Zhao, Xun Huang, Yong-Qiang Deng, **ao-Feng Li… in Cell Discovery (2021)

Article

The METTL3/MALAT1/PTBP1/USP8/TAK1 axis promotes pyroptosis and M1 polarization of macrophages and contributes to liver fibrosis

Pro-inflammatory M1 macrophages, via activating hepatic stellate cells, contribute to liver fibrosis. In this study, we examined the mechanism and the significance of a signaling axis, METTL3/MALAT1/PTBP1/USP8...

Bo Shu, Ying-**a Zhou, Hao Li, Rui-Zhi Zhang, Chao He, **n Yang in Cell Death Discovery (2021)

Article

A single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy

Metastasis is the primary cause of cancer-related mortality in colorectal cancer (CRC) patients. How to improve therapeutic options for patients with metastatic CRC is the core question for CRC treatment. Howe...

Li-Heng Che, **g-Wen Liu, Jian-** Huo, Rong Luo, Rui-Ming Xu, Cai He… in Cell Discovery (2021)

Article

Dipeptidyl peptidase-4 (DPP4) inhibitor sitagliptin alleviates liver inflammation of diabetic mice by acting as a ROS scavenger and inhibiting the NFκB pathway

As a common chronic metabolic disease, the development of diabetes mellitus (DM) may also be accompanied by liver damage and inflammatory disorders. Sitagliptin is an inhibitor of dipeptidyl peptidase-4 (DPP4,...

**n Wang, **g Ke, Ying-jun Zhu, Bin Cao, Rui-li Yin, Yan Wang… in Cell Death Discovery (2021)

Article

SARS-CoV-2 infection in the mouse olfactory system

SARS-CoV-2 infection causes a wide spectrum of clinical manifestations in humans, and olfactory dysfunction is one of the most predictive and common symptoms in COVID-19 patients. However, the underlying mecha...

Qing Ye, Jia Zhou, Qi He, Rui-Ting Li, Guan Yang, Yao Zhang, Shu-Jia Wu… in Cell Discovery (2021)

Article

Author Correction: CRISPR-Cas12a-assisted nucleic acid detection

In the original version of the Supplementary Information file associated with this Article, the site ‘rs5082’ was incorrectly given and should be corrected to ‘rs5028’.

Shi-Yuan Li, Qiu-**ang Cheng, **g-Man Wang, **ao-Yan Li, Zi-Long Zhang… in Cell Discovery (2019)

Article

A chemical approach for global protein knockdown from mice to non-human primates

Although conventional genetic modification approaches for protein knockdown work very successfully due to the increasing use of CRISPR/Cas9, effective techniques for achieving protein depletion in adult animal...

**uyun Sun, Jun Wang, **a Yao, Wen Zheng, Yang Mao, Tianlong Lan… in Cell Discovery (2019)

Article

A two-microRNA-based signature predicts first-line chemotherapy outcomes in advanced colorectal cancer patients

Prognostic and predictive markers are needed to predict the clinical outcomes of patients with advanced colorectal cancer (CRC) who receive standard first-line treatments. We performed a prospective cohort stu...

Jia-huan Lu, Zhi-xiang Zuo, Wei Wang, Qi Zhao, Miao-zhen Qiu… in Cell Death Discovery (2018)