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Article
Development and evaluation of albumin binder-conjugated heterodimeric radiopharmaceuticals targeting integrin αvβ3 and CD13 for cancer therapy
The advancement of heterodimeric tracers, renowned for their high sensitivity, marks a significant trend in the development of radiotracers for cancer diagnosis. Our prior work on [68Ga]Ga-HX01, a heterodimeric t...
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Article
The generalization of strong anisotropic XXZ model and UC hierarchy
This paper is concerned with the construction of the generalized strong anisotropic XXZ model. By means of the quantum inverse scattering method and boson-fermion correspondence, we investigate the general sta...
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Article
Effects of an intraoperative intravenous Bolus Dose of Dexmedetomidine on postoperative catheter-related bladder discomfort in male patients undergoing transurethral resection of bladder tumors: a randomized, double-blind, controlled trial
To investigate whether the effect of intravenous bolus doses of dexmedetomidine on postoperative catheter-related bladder discomfort (CRBD) was dose-dependent in male patients undergoing transurethral resectio...
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Article
Occurrence, distribution and risk assessment of polycyclic aromatic hydrocarbons in soils around main water source areas of Bei**g, China
Polycyclic aromatic hydrocarbons (PAHs) in urban environments have been globally concerned due to their significant health impacts on residents. However, little is known about potential risks of PAHs from cent...
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Article
Open AccessA risk signature of ubiquitin-specific protease family predict the prognosis and therapy of kidney cancer patients
Ubiquitin-specific proteases (USPs) are closely related to protein fate and cellular processes through various molecular signalling pathways, including DNA damage repair, p53, and transforming growth factor-β ...
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Article
Open AccessPeptide-based PET imaging agent of tumor TIGIT expression
Accumulating studies have demonstrated that elevated TIGIT expression in tumor microenvironment correlates with better therapeutic response to TIGIT-based immunotherapy in pre-clinical studies. Therefore, a no...
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Article
Open AccessExtinction drives a discontinuous temporal pattern of species–area relationships in a microbial microcosm system
As the most potential ecological "law", the mechanism of the species-area relationship (SAR) remains controversial. Essentially, the SAR addresses the relationship between regional area and biodiversity, shape...
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Article
Open AccessApoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy
Cancer stem cells (CSCs) are crucial for the growth, metastasis, drug resistance, recurrence, and spread of tumors. Napabucasin (NAP) could effectively inhibit CSC, but its mechanism has not been fully explain...
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Article
Chlorin e6-loaded goat milk-derived extracellular vesicles for Cerenkov luminescence-induced photodynamic therapy
Photodynamic therapy (PDT) is a promising cancer treatment strategy with rapid progress in preclinical and clinical settings. However, the limitations in penetration of external light and precise delivery of phot...
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Chapter and Conference Paper
Deep Knowledge Tracing with Concept Trees
Knowledge tracing aims to diagnose the student’s knowledge status and predict the responses to the next questions, which is a critical task in personalized learning. The existing studies consider more academic...
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Article
Open AccessAnalgesia Effect of Ultrasound-Guided Transversus Abdominis Plane Block Combined with Intravenous Analgesia After Cesarean Section: A Double-Blind Controlled Trial
Complete postoperative analgesia is very important for puerperae after cesarean section. The objective of this study was to explore the optimal postoperative analgesia after cesarean section.
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Article
Open AccessIntegrative analysis of plasma metabolomics and proteomics reveals the metabolic landscape of breast cancer
Breast cancer (BC) is the most commonly diagnosed cancer. Currently, mammography and breast ultrasonography are the main clinical screening methods for BC. Our study aimed to reveal the specific metabolic prof...
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Article
Multi-antitumor therapy and synchronous imaging monitoring based on exosome
Tumor-derived exosomes (TEX) have shown great potential for drug delivery and tumor targeting. Here, we developed a novel multi-drug loaded exosomes nanoprobe for combined antitumor chemotherapy and photodynam...
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Article
Open AccessApplication of Ultrasound-Guided Transversus Abdominis Plane Block Combined with Nalbuphine Patient-Controlled Intravenous Analgesia in Postoperative Analgesia After Laparotomy: A Randomized Controlled Trial
Pain is a common postoperative complication. The ideal postoperative analgesia is awake, safe, mobile, and without side effects. The objective of this study is to provide new ideas for postoperative analgesia ...
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Article
Open AccessSingle-cell N6-methyladenosine regulator patterns guide intercellular communication of tumor microenvironment that contribute to colorectal cancer progression and immunotherapy
N6-methyladenosine (m6A) RNA methylation plays a critical role in key genetic events for various cancers; yet, how m6A functions within the tumor microenvironment (TME) remains to be elucidated.
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Article
Open AccessMinimizing adverse effects of Cerenkov radiation induced photodynamic therapy with transformable photosensitizer-loaded nanovesicles
Photodynamic therapy (PDT) is a promising antitumor strategy with fewer adverse effects and higher selectivity than conventional therapies. Recently, a series of reports have suggested that PDT induced by Cere...
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Article
Open AccessHGF/c-Met pathway facilitates the perineural invasion of pancreatic cancer by activating the mTOR/NGF axis
Perineural invasion (PNI) is a pathologic feature of pancreatic cancer and is associated with poor outcomes, metastasis, and recurrence in pancreatic cancer patients. However, the molecular mechanism of PNI re...
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Article
Effect of Flurbiprofen Axetil on Postoperative Analgesia Following Abdominal Surgery: a Single-Center, Prospective Randomized Controlled Trial
Flurbiprofen axetil has been proved as an alternative analgesia for postoperative pain. The aim of this study was to investigate the effects of different strategies of flurbiprofen axetil administration on pos...
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Article
Open AccessResponse to PD-1-Based Immunotherapy for Non-Small Cell Lung Cancer Altered by Gut Microbiota
This study was designed to identify a group of bacteria in the human gut microbiota with specific effects on PD-1-based immunotherapy for patients with non-small cell lung cancer (NSCLC).
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Article
Diagnostic performance of corrected FFRCT metrics to predict hemodynamically significant coronary artery stenosis
To determine the diagnostic performance of the fractional flow reserve (FFR) derived from coronary computed tomography angiography (CCTA) (FFRCT) difference across the lesion (ΔFFRCT lesion) or the vessel (ΔFFRCT...
