7 Result(s)
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Ruby Yanru Chen-Tsai
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Article
Open AccessEstablishment of a Cre-rat resource for creating conditional and physiological relevant models of human diseases
The goal of this study is to establish a Cre/loxP rat resource for conditional and physiologically predictive rat models of human diseases. The laboratory rat (R. norvegicus) is a central experimental animal in s...
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Protocol
Integrase-Mediated Targeted Transgenics Through Pronuclear Microinjection
Transgenic technology allows a gene of interest to be introduced into the genome of a laboratory animal and provides an extremely powerful tool to dissect the molecular mechanisms of disease. Transgenic mouse ...
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Article
Open AccessHemophilia A ameliorated in mice by CRISPR-based in vivo genome editing of human Factor VIII
Hemophilia A is a monogenic disease with a blood clotting factor VIII (FVIII) deficiency caused by mutation in the factor VIII (F8) gene. Current and emerging treatments such as FVIII protein injection and gene t...
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Protocol
Using TARGATT™ Technology to Generate Site-Specific Transgenic Mice
The discovery of new gene editing tools in the past several years has moved the transgenic field to a new level. The traditional random transgenesis method by pronuclear microinjection has been largely replace...
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Article
Genome editing in livestock: Are we ready for a revolution in animal breeding industry?
Genome editing is a powerful technology that can efficiently alter the genome of organisms to achieve targeted modification of endogenous genes and targeted integration of exogenous genes. Current genome-editi...
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Article
Open AccessHighly efficient CRISPR/Cas9-mediated transgene knockin at the H11 locus in pigs
Transgenic pigs play an important role in producing higher quality food in agriculture and improving human health when used as animal models for various human diseases in biomedicine. Production of transgenic ...
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Article
Genome editing and animal models
Transgenic technology allows a gene of interest to be introduced into the genome of a laboratory animal, and provides an extremely powerful tool to dissect the molecular mechanisms of disease. Transgenic mouse...
