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Article
Open AccessThe cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1
Macrophage-expressed gene 1 (MPEG1/Perforin-2) is a perforin-like protein that functions within the phagolysosome to damage engulfed microbes. MPEG1 is thought to form pores in target membranes, however, its m...
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Article
Open AccessThe first transmembrane region of complement component-9 acts as a brake on its self-assembly
Complement component 9 (C9) functions as the pore-forming component of the Membrane Attack Complex (MAC). During MAC assembly, multiple copies of C9 are sequentially recruited to membrane associated C5b8 to fo...
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Article
Open AccessInhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma
An array of oncogenic histone point mutations have been identified across a number of different cancer studies. It has been suggested that some of these mutant histones can exert their effects by inhibiting ep...
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Article
Open AccessStructure of the poly-C9 component of the complement membrane attack complex
The membrane attack complex (MAC)/perforin-like protein complement component 9 (C9) is the major component of the MAC, a multi-protein complex that forms pores in the membrane of target pathogens. In contrast ...
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Article
Open AccessMaspin is not required for embryonic development or tumour suppression
Maspin (SERPINB5) is accepted as an important tumour suppressor lost in many cancers. Consistent with a critical role in development or differentiation maspin knockout mice die during early embryogenesis, yet ...
