3 Result(s)

Article

Response to correspondence on “Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation”

Channabasavaiah B. Gurumurthy, Aidan R. O’Brien, Rolen M. Quadros… in Genome Biology (2021)

Article

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation

CRISPR-Cas9 gene-editing technology has facilitated the generation of knockout mice, providing an alternative to cumbersome and time-consuming traditional embryonic stem cell-based methods. An earlier study re...

Channabasavaiah B. Gurumurthy, Aidan R. O’Brien, Rolen M. Quadros… in Genome Biology (2019)

Article

Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling

DEPDC5 mutations have recently been shown to cause epilepsy in humans. Evidence from in vitro studies has implicated DEPDC5 as a negative regulator of mTORC1 during amino acid insufficien...

James Hughes, Ruby Dawson, Melinda Tea, Dale McAninch, Sandra Piltz… in Scientific Reports (2017)