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    Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia

    Individuals with Chuvash polycythemia have an increased red blood cell count and are prone to develo** blood clots. Although mutations affecting the VHL protein are known to be causative, the underlying mole...

    Ryan C Russell, Roxana I Sufan, Bing Zhou, Pardeep Heir, Severa Bunda… in Nature Medicine (2011)