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Article
LAPTM4B-35 overexpression is a risk factor for tumor recurrence and poor prognosis in hepatocellular carcinoma
Lysosomal protein transmembrane 4 beta-35 (LAPTM4B-35) is a tetra-transmembrane glycoprotein that is abundantly localized on membrane-bound organelles including endosomes and lysosomes, and promotes cell proli...
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Article
Inhibition of the activating signals in NK92 cells by recombinant GST-sHLA-G1α chain
The soluble HLA-G1 (sHLA-G1) isoform was found to be secreted by trophoblast cells at the materno-fetal interface, which suggests that it may act as an immunomodulator during pregnancy. In this paper, we repor...
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Article
Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma
Lysosomal-associated protein transmembrane-4 beta (LAPTM4B), a novel gene upregulated in hepatocellular carcinoma (HCC), was cloned using fluorescence differential display, RACE, and RT–PCR. It contains seven exo...
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Article
Preparation and identification of monoclonal antibodies against the extracellular domain of integrin α6 subunit-the specific laminin receptor
Objective: To prepare monoclonal antibody (McAb) against the Integrin α6 extracellular domain and identify its biological activities. Methods: Fusion-protein of integrin α6 extracellular domain (GST-IAGED) was...
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Article
Effects of laminin glycopeptides on metastasis-related behaviors of cancer cells
Our previous reports have shown that laminin-glycopeptides (LN-GPs), the total glycopeptides prepared from laminin (LN), can prevent the experimental lung metastasis and liver metastasis of mouse cancer cells....
