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Article
Open AccessExperimental validation of methods for differential gene expression analysis and sample pooling in RNA-seq
Massively parallel cDNA sequencing (RNA-seq) experiments are gradually superseding microarrays in quantitative gene expression profiling. However, many biologists are uncertain about the choice of differential...
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Article
Open AccessComparison of linkage and association strategies for quantitative traits using the COGA dataset
Genome scans using dense single-nucleotide polymorphism (SNP) data have recently become a reality. It is thought that the increase in information content for linkage analysis as a result of the denser scans wi...
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Article
Open AccessGenomic screening in family-based association testing
Due to the recent gains in the availability of single-nucleotide polymorphism data, genome-wide association testing has become feasible. It is hoped that this additional data may confirm the presence of diseas...