6 Result(s)
within
Ross Lazarus
Life Sciences
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Article
Open AccessExperimental validation of methods for differential gene expression analysis and sample pooling in RNA-seq
Massively parallel cDNA sequencing (RNA-seq) experiments are gradually superseding microarrays in quantitative gene expression profiling. However, many biologists are uncertain about the choice of differential...
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Article
Open AccessGenetic adaptation of the antibacterial human innate immunity network
Pathogens have represented an important selective force during the adaptation of modern human populations to changing social and other environmental conditions. The evolution of the immune system has therefore...
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Article
Open AccessQuantifying differential gene connectivity between disease states for objective identification of disease-relevant genes
Network modeling of whole transcriptome expression data enables characterization of complex epistatic (gene-gene) interactions that underlie cellular functions. Though numerous methods have been proposed and s...
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Article
Open AccessPlatform dependence of inference on gene-wise and gene-set involvement in human lung development
With the recent development of microarray technologies, the comparability of gene expression data obtained from different platforms poses an important problem. We evaluated two widely used platforms, Affymetri...
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Article
Open AccessComparison of linkage and association strategies for quantitative traits using the COGA dataset
Genome scans using dense single-nucleotide polymorphism (SNP) data have recently become a reality. It is thought that the increase in information content for linkage analysis as a result of the denser scans wi...
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Article
Open AccessGenomic screening in family-based association testing
Due to the recent gains in the availability of single-nucleotide polymorphism data, genome-wide association testing has become feasible. It is hoped that this additional data may confirm the presence of diseas...
