5 Result(s)
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Article
Open AccessThe impact of complex karyotype on the overall survival of patients with relapsed chronic lymphocytic leukemia treated with idelalisib plus rituximab
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Article
WR-2721 (amifostine) infusion in patients with Ewing's sarcoma receiving ifosfamide and cyclophosphamide with mesna: drug and thiol levels in plasma and blood cells, a Pediatric Oncology Group study
Purpose: Previous WR-2721 human pharmacokinetic studies were limited to plasma levels in patients receiving platinum-based compounds, and none includes the effects of WR-2721 on endogenous thiols. In the present...
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Article
Determination of the cytoprotective agent WR-2721 (Amifostine, Ethyol®) and its metabolites in human blood using monobromobimane fluorescent labeling and high-performance liquid chromatography
Purpose: WR-2721 [S-2-(3-aminopropylamino)ethylphosphorothioic acid] is a chemoprotective agent that is currently in pediatric clinical trials. It is a prodrug that is dephosphorylated by alkaline phosphatase to...
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Article
Pharmacokinetics of WR-2721 [Amifostine, Ethyol®, S-2-(3 Aminopropylamino)Ethylphosphorothioic Acid] in Patients with Metastatic Ewing's Sarcoma (Pediatric Oncology Group Study) 799
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Article
902 SEVERE CEREBELLAR DEGENERATION AND DELAYED ONSET ATAXIA IN HISTIOCYTOSIS X
A rare, and poorly understood syndrome of progressive cerebellar ataxia can be seen in pts. with Histiocytosis X. We report two patients who had bone involvement of the skull and orbit, and developed delayed o...
