36 Result(s)
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Open AccessHYDROchlorothiazide versus placebo to PROTECT polycystic kidney disease patients and improve their quality of life: study protocol and rationale for the HYDRO-PROTECT randomized controlled trial
Autosomal dominant polycystic kidney disease (ADPKD) leads to progressive renal cyst formation and loss of kidney function in most patients. Vasopressin 2 receptor antagonists (V2RA) like tolvaptan are current...
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Open AccessInsulin resistance, kidney outcomes and effects of the endothelin receptor antagonist atrasentan in patients with type 2 diabetes and chronic kidney disease
Insulin resistance (IR) is a pathophysiologic hallmark of type 2 diabetes and associated with the presence of chronic kidney disease (CKD). Experimental studies suggest that endothelin-1 increases IR. We asses...
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Open AccessMicronutrient deficiencies and new-onset atrial fibrillation in a community-based cohort: data from PREVEND
Malnutrition has been linked to cardiovascular diseases. Both selenium and iron deficiency have been associated with worse prognosis in patients with heart failure (HF). Yet, little is known about the role of ...
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Open AccessValidation of a semi-automatic method to measure total liver volumes in polycystic liver disease on computed tomography — high speed and accuracy
Polycystic liver disease (PLD) is characterized by growth of hepatic cysts, causing hepatomegaly. Disease severity is determined using total liver volume (TLV), which can be measured from computed tomography (...
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Open AccessSustained employment, work disability and work functioning in CKD patients: a cross-sectional survey study
Kidney failure negatively affects opportunities for work participation. Little is known about work functioning of employed CKD patients. This study investigates work-related outcomes, and examines associations...
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Open AccessDevelopment and implementation of work-oriented clinical care to empower patients with kidney disease: an adapted intervention map** approach
Many people with chronic kidney disease (CKD) have problems to stay at work. Patients and health care professionals (HCPs) see the potential benefit of work-oriented clinical care, yet this care is not manifes...
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Open AccessThe impact of pre-transplantation nephrectomy on quality of life in patients with autosomal dominant polycystic kidney disease
In selected ADPKD patients, a nephrectomy is required in the work-up for a kidney transplantation. Because the impact of this procedure is unknown, we investigated the effect of pre-transplantation nephrectomy...
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Informing clinical decision making during a pandemic — a call for better preparedness
The COVID-19 pandemic exposed flaws in the ability of the nephrology community to efficiently inform clinical decision making. To improve preparedness for the next pandemic, the nephrology community must work ...
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Article
Open AccessSexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease
Serum selenium levels have been associated with the incidence of heart failure (HF) and signs of the metabolic syndrome. In addition, notable differences have been reported between males and females in food in...
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Open AccessDrugs in Clinical Development to Treat Autosomal Dominant Polycystic Kidney Disease
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst formation that ultimately leads to kidney failure in most patients. Approximately 10% of patients who receive kidney re...
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Open AccessIncident Gallstones During Somatostatin Analog Treatment are Associated with Acute Biliary Complications Especially After Discontinuation
Gallstones are a known adverse effect of somatostatin analogs, but the exact incidence and clinical implications are unknown.
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Open AccessEvaluation of the Pharmacokinetics and Exposure–Response Relationship of Dapagliflozin in Patients without Diabetes and with Chronic Kidney Disease
Dapagliflozin, a sodium-glucose co-transporter inhibitor, was originally developed as an oral glucose-lowering drug for the treatment of type 2 diabetes mellitus. Emerging data suggest that cardiovascular and ...
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CKD is a key risk factor for COVID-19 mortality
A new study uses the OpenSAFELY health analytics platform to identify risk factors for COVID-19 mortality. This analysis, which includes data for more than 17 million people in the UK, suggests that patients w...
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Renal stones in patients with autosomal dominant polycystic kidney disease, a treatment challenge?
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Open AccessPharmacological treatment of increased vascular risk and cognitive performance in middle-aged and old persons: six-year observational longitudinal study
Lowering vascular risk is associated with a decrease in the prevalence of cardiovascular disease and dementia. However, it is still unknown whether lowering of vascular risk with pharmacological treatment pres...
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Open AccessSerum free thiols predict cardiovascular events and all-cause mortality in the general population: a prospective cohort study
Serum free thiols (R-SH, sulfhydryl groups) reliably reflect systemic oxidative stress. Since serum free thiols are rapidly oxidized by reactive species, systemic oxidative stress is generally associated with ...
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Open AccessA rapid high-performance semi-automated tool to measure total kidney volume from MRI in autosomal dominant polycystic kidney disease
To develop a high-performance, rapid semi-automated method (Sheffield TKV Tool) for measuring total kidney volume (TKV) from magnetic resonance images (MRI) in patients with autosomal dominant polycystic kidne...
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Article
Albuminuria as a cause of hypertension
A genetic study using a Mendelian randomization approach provides evidence that albuminuria — as well as being the result of hypertension — might also cause hypertension and cardiometabolic disease. We suggest...
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Open AccessEffect of plasma sodium concentration on blood pressure regulators during hemodialysis: a randomized crossover study
Intradialytic hypotension is a common complication of hemodialysis. The Hemocontrol biofeedback system, improving intradialytic hemodynamic stability, is associated with an initial transient increase in plasma...
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Open AccessCase report: a thiazide diuretic to treat polyuria induced by tolvaptan
Currently, the vasopressin V2 receptor antagonist tolvaptan is the only available treatment for autosomal dominant polycystic kidney disease (ADPKD), but there are tolerability issues due to aquaretic side-eff...
