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Article
Open AccessModelling the lymphatic metastatic progression pathways of OPSCC from multi-institutional datasets
The elective clinical target volume (CTV-N) in oropharyngeal squamous cell carcinoma (OPSCC) is currently based mostly on the prevalence of lymph node metastases in different lymph node levels (LNLs) for a giv...
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Article
Open AccessThe clinical acceptability of short versus long duration acquisitions for head and neck cancer using long-axial field-of-view PET/CT: a retrospective evaluation
To evaluate the utility of long duration (10 min) acquisitions compared to standard 4 min scans in the evaluation of head and neck cancer (HNC) using a long-axial field-of-view (LAFOV) system in 2-[18F]FDG PET...
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Article
Open AccessDifferentiated Papillary NUT Carcinoma: An Unexpected, Deceptively Bland Presentation of a Sinonasal Carcinoma
In recent years, the list of tumor entities in the sinonasal tract has significantly expanded, requiring advanced diagnostic testing. We report the case of a 32-year-old patient with an unusual NUT carcinoma o...
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Article
Open AccessSinonasal malignancies: histopathological entities, regional involvement and long-term outcome
To assess a large patient cohort with sinonasal malignancies focusing on regional involvement, recurrence and oncological outcome.
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Article
Open AccessVoiceS: voice quality after transoral CO2 laser surgery versus single vocal cord irradiation for unilateral stage 0 and I glottic larynx cancer—a randomized phase III trial
Surgery and radiotherapy are well-established standards of care for unilateral stage 0 and I early-stage glottic cancer (ESGC). Based on comparative studies and meta-analyses, functional and oncological outcom...
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Article
Open AccessPatterns of airway obstruction of non-acquired origin in children with and without major congenital anomalies
Major congenital anomalies are known to play a role in the management and prognosis of airway obstruction. Most studies assess acquired forms of airway obstruction. Data on congenital or otherwise non-acquired...
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Ernährungsmanagement und perioperative Immunonutrition
Patienten mit Kopf-Hals-Tumoren sind aufgrund des oft noxen-haltigen Lebensstils, der Erkrankung im oberen Digestivtrakt, der ungenügenden Nahrungszufuhr und den therapeutischen Folgen (z. B. Schmerzen, Schluc...
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Article
Open AccessPrimary neoplasms of the parapharyngeal space: diagnostic and therapeutic pearls and pitfalls
Parapharyngeal space neoplasms (PSNs) are rare tumors of the head and neck region. In this study, we report our institutional experience with PSNs over a 27-years period.
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Article
Correction to: Perioperative predictors of early surgical revision and flap-related complications after microvascular free tissue transfer in head and neck reconstructions: a retrospective observational series
A Correction to this paper has been published: https://doi.org/10.1007/s00784-021-03883-y
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Article
Open AccessPerioperative predictors of early surgical revision and flap-related complications after microvascular free tissue transfer in head and neck reconstructions: a retrospective observational series
The aim of this study was to determine the influence of perioperative fluid management and administration of vasopressors on early surgical revision and flap-related complications in free tissue transfer.
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Article
Open AccessUnplanned hospitalizations in patients with locoregionally advanced head and neck cancer treated with (chemo)radiotherapy with and without prophylactic percutaneous endoscopic gastrostomy
Current studies about percutaneous endoscopic gastrostomy (PEG) tube placement report equivalent patient outcomes with prophylactic PEG tubes (pPEGs) versus common nutritional support. Unreported was if omitti...
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Surgical Anatomy of the Neck
The neck affords one of the most surgically complex anatomy in the human body, as it contains vital or otherwise functionally relevant structures. Among these are the upper aero-digestive tract, the great neck...
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Chapter
Surgical Approaches and Operative Techniques for Cervical Lymph Node Pathology
Management of the neck lymph nodes is an integral part in the therapeutic approach of head and neck cancer. Within this context, neck dissection entails the removal of nodal levels contained in the cervical so...
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Article
Open AccessLong-term functional outcome after laryngeal cancer treatment
The functional outcome after the treatment of laryngeal cancer is tightly related to the quality of life of affected patients. The aim of this study is to describe the long-term morbidity and functional outcom...
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Article
Open AccessEffect of preoperative immunonutrition on complications after salvage surgery in head and neck cancer
Patients undergoing salvage surgery for recurrent head and neck squamous cell carcinoma are at high risk of postoperative complications due to the adverse effects of radiotherapy on wound healing. Malnutrition...
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Article
Open AccessRelation of baseline neutrophil-to-lymphocyte ratio to survival and toxicity in head and neck cancer patients treated with (chemo-) radiation
A high neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation and together with the platelet-to-lymphocyte ratio (PLR) is associated with worse outcomes in several solid tumors. We investiga...
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Article
Recurrent parotid gland carcinoma: how effective is salvage surgery?
Recurrent parotid gland carcinomas (PGCs) are poorly characterized and studies focusing on this topic are rare due to their low incidence. The goal of this study is to analyze the therapeutic strategies, progn...
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Article
T1–2 glottic cancer treated with radiotherapy and/or surgery
The optimal treatment strategy for stage I–II glottic squamous cell carcinoma (SCC) is not well-defined. This study analyzed treatment results and prognostic factors.
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Article
Open AccessPIK3CA hotspot mutations differentially impact responses to MET targeting in MET-driven and non-driven preclinical cancer models
The MET receptor tyrosine kinase represents a promising target in cancer. PIK3CA activating mutations are common in several tumor types and can potentially confer resistance to anti-receptor tyrosine kinase th...
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Article
Pectoralis major myofascial interposition flap prevents postoperative pharyngocutaneous fistula in salvage total laryngectomy
Pharyngocutaneous fistula (PCF) is the most cumbersome complication after salvage total laryngectomy (STL) in patients who have been previously irradiated for laryngeal or hypopharyngeal cancer. To assess the ...
