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Article
Open AccessLDexpress: an online tool for integrating population-specific linkage disequilibrium patterns with tissue-specific expression data
Genome-wide association studies have identified thousands of genetic susceptibility loci associated with cancer as well as other traits and diseases. Map** germline variation in identified genetic susceptibi...
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Article
Open AccessA large Canadian cohort provides insights into the genetic architecture of human hair colour
Hair colour is a polygenic phenotype that results from differences in the amount and ratio of melanins located in the hair bulb. Genome-wide association studies (GWAS) have identified many loci involved in the...
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Article
Open AccessResolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1
The response of patients with recurrent glioblastoma multiforme to neoadjuvant immune checkpoint blockade has been challenging to interpret due to the inter-patient and intra-tumor heterogeneity. We report on ...
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Article
Open AccessTumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy
Anti-PD-1 therapy is used as a front-line treatment for many cancers, but mechanistic insight into this therapy resistance is still lacking. Here we generate a humanized (Hu)-mouse melanoma model by injecting ...
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Chapter and Conference Paper
Optimization of Process Parameters in Micro-EDM Through Mixed Flushing and GRA Technique
Diesinker electric discharge machining is a widely used non-traditional technique to make highly precise and complex geometry parts. In this paper, the effects of material density of electrode (copper, alumini...
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Article
Open AccessStroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma
Although immune checkpoint inhibitors (ICIs) have achieved unprecedented results in melanoma, the biological features of the durable responses initiated by these drugs remain unknown. Here we show the genetic ...
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Article
B cells and tertiary lymphoid structures promote immunotherapy response
Treatment with immune checkpoint blockade (ICB) has revolutionized cancer therapy. Until now, predictive biomarkers1–10 and strategies to augment clinical response have largely focused on the T cell compartment. ...
