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Article
Open AccessTargeted sampling of natural product space to identify bioactive natural product-like polyketide macrolides
Polyketide or polyketide-like macrolides (pMLs) continue to serve as a source of inspiration for drug discovery. However, their inherent structural and stereochemical complexity challenges efforts to explore r...
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Article
Open AccessMultivariate pattern analysis: a method and software to reveal, quantify, and visualize predictive association patterns in multicollinear data
Strongly multicollinear covariates, such as those typically represented in metabolomics applications, represent a challenge for multivariate regression analysis. These challenges are commonly circumvented by r...
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Article
Artificial intelligence for natural product drug discovery
Developments in computational omics technologies have provided new means to access the hidden diversity of natural products, unearthing new potential for drug discovery. In parallel, artificial intelligence ap...
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Article
Open AccessCollateral sensitivity profiling in drug-resistant Escherichia coli identifies natural products suppressing cephalosporin resistance
The rapid emergence of antimicrobial resistance presents serious health challenges to the management of infectious diseases, a problem that is further exacerbated by slowing rates of antimicrobial drug discove...
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Article
Open AccessAnnotation of natural product compound families using molecular networking topology and structural similarity fingerprinting
Spectral matching of MS2 fragmentation spectra has become a popular method for characterizing natural products libraries but identification remains challenging due to differences in MS2 fragmentation properties b...
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Article
An isotopic labeling approach linking natural products with biosynthetic gene clusters
Major advances in genome sequencing and large-scale biosynthetic gene cluster (BGC) analysis have prompted an age of natural product discovery driven by genome mining. Still, connecting molecules to their cogn...
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Article
A selective genome-guided method for environmental Burkholderia isolation
The genus Burkholderia is an emerging source of novel natural products chemistry, yet to date few methods exist for the selective isolation of strains of this genus from the environment. More broadly, tools to ef...
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Article
Open AccessData-analysis strategies for image-based cell profiling
This Review covers the steps required to create high-quality image-based profiles from high-throughput microscopy images.
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Article
Open AccessSansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis
Tuberculosis (TB) is responsible for enormous global morbidity and mortality, and current treatment regimens rely on the use of drugs that have been in use for more than 40 years. Owing to widespread resistanc...
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Article
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
GNPS is an open-access community-curated analysis platform for sharing natural product mass spectrometry data that enables continuous, automatic reanalysis of deposited 'living' data sets.
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Article
Living in the matrix: assembly and control of Vibrio cholerae biofilms
Biofilms of Vibrio cholerae, the causative agent of cholera, have an important role during the aquatic and intestinal phases of the bacterial life cycle, confe...
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Article
MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus
Most (75%) of the anti-infectives that save countless lives and enormously improve quality of life originate from microbes found in nature. Herein, we described a global visualization of the detectable molecul...
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Article
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds
A single trimethylated species is obtained in an on-resin N-methylation reaction of a cyclic hexapeptide. This regioselectivity is driven by conformation and the presence of intramolecular hydrogen bonds, and ...
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Chapter and Conference Paper
De Novo Sequencing of Nonribosomal Peptides
While nonribosomal peptides (NRPs) are of tremendous pharmacological importance, there is currently no technology capable of high-throughput sequencing of NRPs. Difficulties in sequencing NRPs slow down the pr...
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Article
Linking bioprospecting with sustainable development and conservation: the Panama case
The limited international resources for economic aid and conservation can only mitigate poverty and losses of biodiversity. Hence, develo** nations must establish the capacity to resolve their problems. Addi...
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Article
De Novo terpenoid biosynthesis by the dendronotid nudibranch Melibe leonina
Stable isotope feeding studies using [1,2-13C2]-sodium acetate have demonstrated that 2,6-dimethyl-5-heptenal (1), a putative defensive allomone, is made by the Dendronotid nudibranch Melibe leonina via de novo ...
