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Article
Open AccessA promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion
Microbial aromatic catabolism offers a promising approach to convert lignin, a vast source of renewable carbon, into useful products. Aryl-O-demethylation is an essential biochemical reaction to ultimately catabo...
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Article
Open AccessStructure, computational and biochemical analysis of PcCel45A endoglucanase from Phanerochaete chrysosporium and catalytic mechanisms of GH45 subfamily C members
The glycoside hydrolase family 45 (GH45) of carbohydrate modifying enzymes is mostly comprised of β-1,4-endoglucanases. Significant diversity between the GH45 members has prompted the division of this family i...
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Article
Open AccessCorrection: Corrigendum: Molecular characterization of a family 5 glycoside hydrolase suggests an induced-fit enzymatic mechanism
Scientific Reports 6: Article number: 23473; published online: 01 April 2016; updated: 14 December 2016.
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Article
Open AccessMolecular characterization of a family 5 glycoside hydrolase suggests an induced-fit enzymatic mechanism
Glycoside hydrolases (GHs) play fundamental roles in the decomposition of lignocellulosic biomaterials. Here, we report the full-length structure of a cellulase from Bacillus licheniformis (BlCel5B), a member of ...
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Article
Open AccessAllosteric Pathways in the PPARγ-RXRα nuclear receptor complex
Understanding the nature of allostery in DNA-nuclear receptor (NR) complexes is of fundamental importance for drug development since NRs regulate the transcription of a myriad of genes in humans and other meta...