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Article
Open AccessA promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion
Microbial aromatic catabolism offers a promising approach to convert lignin, a vast source of renewable carbon, into useful products. Aryl-O-demethylation is an essential biochemical reaction to ultimately catabo...
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Article
Open AccessStructure, computational and biochemical analysis of PcCel45A endoglucanase from Phanerochaete chrysosporium and catalytic mechanisms of GH45 subfamily C members
The glycoside hydrolase family 45 (GH45) of carbohydrate modifying enzymes is mostly comprised of β-1,4-endoglucanases. Significant diversity between the GH45 members has prompted the division of this family i...
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Article
Open AccessCorrection: Corrigendum: Molecular characterization of a family 5 glycoside hydrolase suggests an induced-fit enzymatic mechanism
Scientific Reports 6: Article number: 23473; published online: 01 April 2016; updated: 14 December 2016.
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Article
Open AccessMolecular characterization of a family 5 glycoside hydrolase suggests an induced-fit enzymatic mechanism
Glycoside hydrolases (GHs) play fundamental roles in the decomposition of lignocellulosic biomaterials. Here, we report the full-length structure of a cellulase from Bacillus licheniformis (BlCel5B), a member of ...
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Article
Open AccessAllosteric Pathways in the PPARγ-RXRα nuclear receptor complex
Understanding the nature of allostery in DNA-nuclear receptor (NR) complexes is of fundamental importance for drug development since NRs regulate the transcription of a myriad of genes in humans and other meta...
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Chapter and Conference Paper
Provenance-Based Retrieval: Fostering Reuse and Reproducibility Across Scientific Disciplines
When computational researchers from several domains cooperate, one recurrent problem is finding tools, methods and approaches that can be used across disciplines, to enhance collaboration through reuse. The pa...
