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Open AccessMorphologic spectrum of the epithelial tumors of the male and female urethra
The classification of the epithelial tumors of the male and female urethra includes benign and malignant neoplasms. Primary urethral carcinomas and adenocarcinomas of the accessory glands are the most relevant...
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Article
Global Real-World Outcomes of Patients Receiving Immuno-Oncology Combinations for Advanced Renal Cell Carcinoma: The ARON-1 Study
Immuno-oncology combinations have achieved survival benefits in patients with metastatic renal cell carcinoma (mRCC).
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Open AccessT1 bladder carcinoma with variant histology: pathological features and clinical significance
The aim of the study was to stratify high-grade T1 (HGT1) bladder urothelial carcinoma into risk categories based on the presence of variant histology when compared to conventional urothelial carcinoma. The cl...
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Article
Open AccessUpdated pathology reporting standards for bladder cancer: biopsies, transurethral resections and radical cystectomies
Optimal management of bladder cancer requires an accurate, standardised and timely pathological diagnosis, and close communication between surgeons and pathologists. Here, we provide an update on pathology rep...
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Chapter
Biomarkers in Urinary Tract and Male Genital System Carcinomas
Increased knowledge of the genomic structure of renal cell carcinoma (RCC) supports the classification of patients for targeted therapies. Immunohistochemical (IHC) markers such as CA-IX, CK7, AMACR, CD117, TFE3,...
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Lesson from the COVID-19 pandemic: pathologists need to build their confidence on working in a digital microscopy environment
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How radical prostatectomy procedures have changed over the last 10 years in Italy: a comparative analysis based on more than 1500 patients participating in the MIRROR-SIU/LUNA and the Pros-IT CNR study
Therapeutic strategies for prostate cancer (PCa) have been evolving dramatically worldwide. The current article reports on the evolution of surgical management strategies for PCa in Italy.
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Considerations on current and future issues related to reproducibility and accuracy in prostate cancer grading
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Protocol
Fluorescence In Situ Hybridization (FISH) Detection of Chromosomal 12p Anomalies in Testicular Germ Cell Tumors
Gains of genetic material or internal rearrangements of chromosome 12p, including 12p overrepresentation or isochromosome 12p [i(12p)], are observed in virtually all germ cell tumors (GCT), in all histologic s...
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Protocol
Molecular Characterization of Testicular Germ Cell Tumors Using Tissue Microdissection
Testicular germ cell tumors are among the most common malignancies seen in children and young adults. Genomic studies have identified characteristic molecular profiles in testicular cancer, which are associate...
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Author Correction: A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Clinicopathologic analysis of upper urinary tract carcinoma with variant histology
We report on the clinicopathologic features of 115 cases of high-grade urothelial carcinoma of the upper urinary tract with variant histology present in 39 (34%). Variant histology was typically seen in high p...
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Article
pT1 high-grade bladder cancer: histologic criteria, pitfalls in the assessment of invasion, and substaging
Most patients with bladder carcinoma are diagnosed with non-muscle-invasive disease, stage Ta, and pT1. Stage remains as the single most important prognostic indicator in urothelial carcinoma. Among the pT1 bl...
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Ex vivo fluorescence confocal microscopy: prostatic and periprostatic tissues atlas and evaluation of the learning curve
Ex vivo fluorescence confocal microscopy (FCM) is an optical technology that provides fast H&E-like images of freshly excised tissues, and it has been mainly used for “real-time” pathological examination of de...
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Systemic Treatment for Metastatic Hormone Sensitive Prostate Cancer: A Comprehensive Meta-Analysis Evaluating Efficacy and Safety in Specific Sub-Groups of Patients
Several systemic treatments are available for metastatic hormone sensitive prostate cancer (mHSPC) including docetaxel (D), abiraterone and prednisone (A + P) and new anti-androgens (NA). In our study we perfo...
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Reference Work Entry In depth
Prostatic Acinar Adenocarcinoma, Atrophic Variant
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Reference Work Entry In depth
Seminal Vesicle Squamous Cell Carcinoma
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Reference Work Entry In depth
Infarct of the Prostate
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Reference Work Entry In depth
Prostatic Acinar Adenocarcinoma, Microcystic Variant
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Reference Work Entry In depth
Prostatic Acinar Adenocarcinoma, Pleomorphic Giant Cell Variant
